Description

T-Boc-Aminooxy-Peg4-Ch2Co2H is a high-purity, heterobifunctional polyethylene glycol (PEG) linker featuring a tert-butyloxycarbonyl (T-Boc) protected aminooxy group and a terminal carboxylic acid. This compound is specifically engineered for the controlled conjugation and bioconjugation of biomolecules, offering a hydrophilic spacer to enhance solubility and reduce immunogenicity. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing antibody-drug conjugates (ADCs), peptide therapeutics, and advanced diagnostic reagents.

Application

• Bioconjugation Reagent: A key intermediate for site-specific conjugation of drugs, dyes, or other payloads to antibodies, proteins, or peptides via oxime ligation.
• ADC (Antibody-Drug Conjugate) Development: Used to construct stable, cleavable, or non-cleavable linkers that connect cytotoxic drugs to monoclonal antibodies.
• PEGylation Chemistry: Serves as a functionalized PEG spacer to modify therapeutic proteins, peptides, or nanoparticles to improve pharmacokinetic profiles.
• Proteomics Research: Employed in chemical biology for labeling, cross-linking, or surface functionalization in assay development.
• Diagnostic Reagent Synthesis: Facilitates the creation of fluorescent or other labeled probes for imaging and diagnostic applications.
• Polymer & Material Science: Acts as a functional monomer or cross-linker for synthesizing smart hydrogels and biocompatible materials.

Basic Information

Product Name	T-Boc-Aminooxy-Peg4-Ch2Co2H
CAS No.	2028281-90-3
Molecular Formula	C22H43NO11
Molecular Weight	497.58 g/mol
Synonyms	1-Boc-2-(2-(2-(2-(2-aminooxyethoxy)ethoxy)ethoxy)ethoxy)acetic acid; (1-Boc-2-(2-(2-(2-(2-aminooxyethoxy)ethoxy)ethoxy)ethoxy)acetic acid); 2-[2-[2-[2-(2-[(2-Methyl-2-propanyl)oxycarbonyl]aminooxyethoxy)ethoxy]ethoxy]ethoxy]acetic Acid; T-Boc-NH-O-PEG4-CH2COOH; Boc-Aminooxy-PEG4-acid; Aminooxy-PEG4-acid t-butyl ester; tert-Butyl (17-carboxy-3,6,9,12-tetraoxa-16-azaheptadecyl)carbamate
EINECS	Contact for details

Quality Control

Our T-Boc-Aminooxy-Peg4-Ch2Co2H is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical R&D and production. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.