Description

Biotinyl-Tau Peptide (306-336) (Repeat 3 Domain) is a synthetic, biotinylated peptide fragment derived from the microtubule-associated protein Tau, specifically encompassing the repeat domain region. This modified peptide is a critical research tool for studying Tau protein aggregation, phosphorylation, and its role in neurodegenerative pathologies such as Alzheimer's disease. It is primarily utilized by pharmaceutical R&D teams, academic neuroscientists, and diagnostic developers for use in immunoassays, protein interaction studies, and as a standard in biomarker research.

Application

• Biomarker Research & Diagnostic Development: Serves as a key antigen and standard for developing and validating immunoassays (ELISA, Western Blot) to detect Tau-related biomarkers in biological fluids.
• Neurodegenerative Disease Research: Essential for in vitro studies investigating Tau protein aggregation mechanisms, phosphorylation kinetics, and the formation of neurofibrillary tangles.
• Drug Discovery Screening: Used in high-throughput screening (HTS) platforms to identify and evaluate potential therapeutic compounds that inhibit Tau aggregation or modulate its interaction with other proteins.
• Antibody Production & Characterization: Acts as an immunogen for generating monoclonal or polyclonal antibodies specific to the Tau repeat domain, or for testing antibody specificity and affinity.
• Pull-Down & Binding Assays: The biotin tag enables efficient immobilization on streptavidin-coated surfaces for studying protein-protein interactions, such as binding to microtubules or other molecular partners.
• Calibration & Quality Control: Provides a defined, pure standard for calibrating analytical instruments and ensuring consistency in experimental workflows across laboratories.

Basic Information

Product Name	Biotinyl-Tau Peptide (306-336) (Repeat 3 Domain)
CAS No.	2022956-58-5
Molecular Formula	C185H294N52O55S
Molecular Weight	~4140.7 g/mol
Synonyms	Biotin-Tau (306-336) Peptide; Biotinylated Tau Peptide Fragment (R3); Tau Protein (306-336), Biotinylated; Biotinyl-Tau Repeat Domain Peptide; Biotin-Tau R3 Peptide; Biotin-conjugated Microtubule-Associated Protein Tau Fragment; Biotin-LC-Tau (306-336); Biotinylated Alzheimer's Tau Peptide
EINECS	Contact for details

Quality Control

Every batch of Biotinyl-Tau Peptide (306-336) (Repeat 3 Domain) is manufactured and analyzed under strict quality protocols to ensure identity, purity, and batch-to-batch consistency suitable for critical research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for purity (HPLC), molecular weight confirmation (MS), and peptide content.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Molecular Weight (MS)	4138 - 4144 Da
Peptide Content	≥ 70%
Solubility	Soluble in water, DMSO, or aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.