Description

(S)-5-((2,5-Dioxopyrrolidin-1-yl)oxy)-5-oxo-2-palmitamidopentanoic Acid is a specialized, high-purity chemical intermediate designed for advanced bioconjugation and linker chemistry. This compound matters for its role as a functionalized building block, enabling the precise attachment of payloads like lipids or probes to biomolecules under controlled conditions. It is primarily needed by researchers and manufacturers in the pharmaceutical, diagnostic, and life science sectors for developing targeted therapeutics, novel assays, and sophisticated research tools.

Application

• Bioconjugation Reagent: Used as a key intermediate for attaching palmitoyl groups or other hydrophobic moieties to peptides, proteins, or antibodies to modify their pharmacokinetic properties.
• Lipidated Peptide Synthesis: Serves as a building block in solid-phase or solution-phase peptide synthesis for the site-specific incorporation of lipid chains, enhancing membrane association.
• ADC (Antibody-Drug Conjugate) Linker Development: Functions as a component in the design of cleavable or non-cleavable linkers, connecting cytotoxic drugs to targeting antibodies.
• Probe and Label Synthesis: Utilized in the creation of fluorescent, biotinylated, or other tagged chemical probes for cellular imaging and biochemical studies.
• Pharmaceutical Intermediates: Acts as a critical precursor in the multi-step synthesis of complex active pharmaceutical ingredients (APIs) with specific targeting functionalities.
• Biomaterial Functionalization: Applied to modify surfaces of nanoparticles or polymers to create biocompatible coatings or targeted delivery systems.

Basic Information

Product Name	(S)-5-((2,5-Dioxopyrrolidin-1-yl)oxy)-5-oxo-2-palmitamidopentanoic Acid
CAS No.	294855-91-7
Molecular Formula	C25H42N2O7
Molecular Weight	482.61 g/mol
Synonyms	N2-Palmitoyl-N6-(2,5-dioxopyrrolidin-1-yloxy-6-oxohexanoyl)-L-lysine; Palmitoyl-Lys(NHS) OH; (S)-2-Palmitamido-6-((2,5-dioxopyrrolidin-1-yl)oxy)-6-oxohexanoic Acid; Nα-Palmitoyl-Nε-succinimidyl-L-lysine; Nε-(N-Succinimidyloxy)-Nα-palmitoyl-L-lysine; L-Lysine, N2-palmitoyl-, 1-(N-succinimidyl) ester; Lipidic NHS-ester linker; Palmitic acid-Lys(NHS)-OH
EINECS	Contact for details

Quality Control

Our (S)-5-((2,5-Dioxopyrrolidin-1-yl)oxy)-5-oxo-2-palmitamidopentanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee compliance with research and cGMP-grade standards for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize condensation. For long-term storage, keep desiccated under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.