Description

Abz-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-Nh2 is a synthetic, fluorogenic peptide substrate designed for high-sensitivity enzymatic assays. This compound matters for researchers and manufacturers requiring precise, reliable tools for studying protease activity, particularly in complex biological matrices. It is primarily needed by the pharmaceutical, biotechnology, and life science research industries for applications in drug discovery, biochemical pathway analysis, and diagnostic development.

Application

• Protease Activity Assays: As a specialized fluorogenic substrate for the detection and quantification of specific protease enzymes in research and development.
• Drug Discovery Screening: Used in high-throughput screening (HTS) platforms to identify and characterize novel protease inhibitors as potential therapeutic agents.
• Biochemical Research: A critical tool for studying enzyme kinetics, substrate specificity, and catalytic mechanisms of proteolytic enzymes.
• Diagnostic Development: Serves as a key component in the development of sensitive in-vitro diagnostic tests for diseases involving dysregulated protease activity.
• Quality Control in Biologics: Employed in the quality control of biopharmaceuticals to monitor and validate the absence of residual protease activity in final products.

Basic Information

Product Name	Abz-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-Nh2
CAS No.	290362-09-3
Molecular Formula	C58H86N16O15
Molecular Weight	1231.4 g/mol
Synonyms	Abz-KPLGL(Dnp)AR-NH2; Fluorogenic Peptide Substrate 290362-09-3; o-Aminobenzoic acid-Lys-Pro-Leu-Gly-Leu-Nε-(2,4-dinitrophenyl)-L-α,β-diaminopropionyl-Ala-Arg-amide; DABCYL-KPLGL(Dnp)AR-EDANS (related quenched fluorogenic substrate); Protease Substrate Peptide; Intramolecularly Quenched Fluorogenic Peptide; IQF Peptide Substrate
EINECS	Contact for details

Quality Control

Our Abz-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-Nh2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via mass spectrometry, to ensure it meets the high standards required for sensitive research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic nature, allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (HPLC)	≥ 98%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.