Description

1,4-Anhydro-2,5-Dideoxy-2-(3,4-Dihydro-5-Methyl-2,4-Dioxo-1(2H)-Pyrimidinyl)-D-Arabino-Hexitol is a high-purity nucleoside derivative, a key building block in advanced pharmaceutical synthesis and biochemical research. Its value lies in its role as a sophisticated intermediate for the development of novel antiviral and anticancer therapeutics, where precise molecular structure is critical for biological activity. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries seeking to innovate in nucleoside-based drug discovery.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel nucleoside analog drugs targeting viral infections and cancer.
• Antiviral Drug Research: Used in the development of next-generation antiviral agents, particularly for DNA viruses.
• Oncology Research: Serves as a building block for creating potential chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Biochemical Probe Development: Utilized in research to study enzyme mechanisms, such as those of polymerases and nucleotidyltransferases.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale manufacturing of active pharmaceutical ingredients (APIs).
• Academic & Institutional Research: A valuable reagent for universities and research institutes exploring carbohydrate and heterocyclic chemistry.

Basic Information

Item	Details
Product Name	1,4-Anhydro-2,5-Dideoxy-2-(3,4-Dihydro-5-Methyl-2,4-Dioxo-1(2H)-Pyrimidinyl)-D-Arabino-Hexitol
CAS No.	289665-64-1
Molecular Formula	C11H16N2O6
Molecular Weight	272.25 g/mol
Synonyms	5-Methyl-2,4-dioxo-1-(2,5-dideoxy-1,4-anhydro-D-arabino-hexitol-2-yl)-1,2,3,4-tetrahydropyrimidine; 1-(2,5-Dideoxy-1,4-anhydro-D-arabino-hexitol-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; Thymidine arabino-hexitol derivative; Nucleoside-modified sugar intermediate; D-Arabino-Hexitol, 1,4-anhydro-2,5-dideoxy-2-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-; 289665-64-1
EINECS	Contact for details

Quality Control

Our 1,4-Anhydro-2,5-Dideoxy-2-(3,4-Dihydro-5-Methyl-2,4-Dioxo-1(2H)-Pyrimidinyl)-D-Arabino-Hexitol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) documenting purity, related substances, and other critical parameters are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.