Description

2'-Deoxy-5'-Dmt-5-Ethenyluridine 3'-Ce Phosphoramidite is a high-purity, modified nucleoside phosphoramidite building block essential for the solid-phase synthesis of oligonucleotides. This compound is critical for introducing specific, non-natural modifications into DNA strands, enabling advanced research and therapeutic development. It is primarily utilized by biotechnology and pharmaceutical companies engaged in antisense technology, siRNA development, and the creation of diagnostic probes.

Application

• Oligonucleotide Synthesis: A key monomer for the automated solid-phase synthesis of modified DNA strands.
• Antisense & siRNA Therapeutics: Used to incorporate the 5-ethenyluridine modification, which can enhance binding affinity and stability of therapeutic oligonucleotides.
• Diagnostic Probe Development: Enables the creation of labeled or modified probes for genetic testing and molecular diagnostics.
• Basic Research: Serves as a crucial reagent in academic and industrial labs studying nucleic acid structure, function, and interactions.
• Synthesis of Modified Aptamers: Facilitates the production of aptamers with tailored properties for sensing or therapeutic applications.

Basic Information

Product Name	2'-Deoxy-5'-Dmt-5-Ethenyluridine 3'-Ce Phosphoramidite
CAS No.	287980-24-9
Molecular Formula	C41H48N3O8P
Molecular Weight	741.81 g/mol
Synonyms	5-Ethenyl-dU-CE Phosphoramidite; 5-Vinyl-dU Phosphoramidite; 2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-5-ethenyluridine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite); 5-Ethenyl-2'-deoxyuridine 3'-CE Phosphoramidite; DMT-5-Ethenyl-dU-CE Phosphoramidite; 5-Vinyl-2'-deoxyuridine phosphoramidite
EINECS	Contact for details

Quality Control

Every batch of 2'-Deoxy-5'-Dmt-5-Ethenyluridine 3'-Ce Phosphoramidite is manufactured and tested under strict quality systems to ensure consistency and reliability for critical oligonucleotide synthesis. Our products undergo rigorous quality testing, including HPLC purity analysis and 31P NMR spectroscopy, to ensure compliance with industry standards for advanced research and GMP starting materials. Certificates of Analysis (COA) detailing purity, identity, and moisture content are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (31P NMR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Moisture Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.