Description

(+/-)-9-Hydroxy-5Z,7E,11Z,14Z,17Z-Eicosapentaenoic Acid CAS NO 286390-03-2 is a specialized hydroxylated derivative of eicosapentaenoic acid (EPA), a key ω-3 fatty acid. This compound serves as a crucial reference standard and biochemical intermediate for research into lipid metabolism, inflammation, and specialized pro-resolving mediators (SPMs). It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers engaged in developing novel therapeutics and analytical methods.

Application

• Biochemical Research Standard: Used as a high-purity reference material in LC-MS, HPLC, and GC analysis for quantifying related eicosanoids and oxylipins in biological samples.
• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of novel anti-inflammatory and pro-resolving lipid mediator drugs.
• Metabolic Pathway Studies: Essential for investigating the enzymatic pathways (e.g., involving lipoxygenases and cytochrome P450s) involved in polyunsaturated fatty acid metabolism.
• Cell Signaling Research: Applied in in vitro and in vivo studies to elucidate the role of hydroxy-EPAs in cellular signaling, inflammation resolution, and immune response modulation.
• Nutritional Science: Used as a standard to study the bioactive metabolites derived from dietary ω-3 fatty acid supplementation.
• Fine Chemical Synthesis: Employed as a building block for the synthesis of more complex, structurally related lipid molecules for biological evaluation.

Basic Information

Product Name	(+/-)-9-Hydroxy-5Z,7E,11Z,14Z,17Z-Eicosapentaenoic Acid
CAS No.	286390-03-2
Molecular Formula	C₂₀H₃₀O₃
Molecular Weight	318.45 g/mol
Synonyms	9-Hydroxy-EPA; 9-Hydroxyeicosapentaenoic Acid; 9-HEPE; (±)-9-Hydroxy-5Z,7E,11Z,14Z,17Z-eicosapentaenoic acid; 9-Hydroxy-5,7,11,14,17-eicosapentaenoic acid; 9(S/R)-HETE; 9-Hydroxy-5,8,11,14,17-eicosapentaenoic acid; 9-Hydroxyall-cis-5,8,11,14,17-eicosapentaenoic acid
EINECS	Contact for details

Quality Control

Our high-purity lipid standards are manufactured under controlled conditions and undergo rigorous analytical testing to ensure identity, purity, and stability. Each batch is characterized using advanced techniques including HPLC, GC-MS, and NMR spectroscopy. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request, supporting compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep away from strong oxidizers.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (IR / NMR)	Conforms to structure
Assay (HPLC)	≥ 95% (Area %)
Purity (GC)	≥ 90%
Solubility	Soluble in ethanol, DMSO, methanol; insoluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.