Description

(3S,5S)-3'-Hydroxycotinine is a specific stereoisomer of a major metabolite of nicotine, offering a high-purity reference standard for analytical and research applications. This compound is critical for ensuring accurate quantification and metabolic profiling in scientific studies. It is primarily utilized by analytical laboratories, pharmaceutical researchers, and diagnostic manufacturers working in the fields of toxicology, nicotine metabolism, and biomarker discovery.

Application

• Analytical Reference Standard: Used as a certified reference material (CRM) for the calibration and validation of analytical methods in HPLC, LC-MS, and GC-MS systems.
• Biomedical Research: Serves as a key metabolite standard in studies investigating nicotine metabolism, pharmacokinetics, and pharmacodynamics.
• Clinical Toxicology: Employed in the development and quality control of diagnostic assays for monitoring nicotine exposure and cessation programs.
• Pharmaceutical Development: Used in research for drug development targeting nicotine addiction and related metabolic pathways.
• Forensic Analysis: Acts as a precise standard in forensic laboratories for the accurate determination of nicotine and its metabolites in biological samples.

Basic Information

Product Name	(3S,5S)-3'-Hydroxycotinine
CAS No.	276799-61-2
Molecular Formula	C10H12N2O2
Molecular Weight	192.22 g/mol
Synonyms	(3S,5S)-3-Hydroxycotinine; trans-3'-Hydroxycotinine; (3S,5S)-1-Methyl-5-(3-pyridyl)-2-pyrrolidinone-3-ol; 3-Hydroxycotinine (specified stereoisomer); Nicotine metabolite 3; Cotinine-3-ol
EINECS	Contact for details

Quality Control

Our (3S,5S)-3'-Hydroxycotinine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for research and reference standards. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, LC-MS) are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (by chiral HPLC)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.