Description

Akt/Skg Substrate Peptide CAS NO 276680-69-4 is a specialized synthetic peptide sequence designed as a selective substrate for Akt (Protein Kinase B) and related kinases. This compound is a critical tool for researchers studying intracellular signaling pathways, particularly those involved in cell survival, proliferation, and metabolism. It is essential for biochemical and cell-based assays in pharmaceutical R&D, academic research, and diagnostic development focused on oncology, metabolic disorders, and neurological diseases.

Application

• Kinase Activity Assays: Primary substrate for in vitro enzymatic assays to measure Akt/PKB activity and screen for kinase inhibitors.
• Drug Discovery & Development: High-throughput screening (HTS) and validation of potential therapeutic compounds targeting the PI3K/Akt/mTOR signaling pathway.
• Biochemical Research: Investigation of kinase substrate specificity, kinetic studies, and mechanism-of-action analysis for signal transduction.
• Diagnostic Kit Development: A key component in ELISA and other immunoassay formats for quantifying kinase activity in clinical and research samples.
• Cell Signaling Studies: Used in cell-based assays to monitor Akt pathway activation or inhibition in response to various stimuli or treatments.
• Quality Control Reagent: Serves as a reference standard and control material in the production and validation of assay kits and research reagents.

Basic Information

Product Name	Akt/Skg Substrate Peptide
CAS No.	276680-69-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Akt Substrate Peptide; SKG Substrate Peptide; Protein Kinase B Substrate; Akt/PKB Substrate; GRPRTSSFAEG; PI3K Pathway Substrate; Kinase Assay Substrate; Cell Signaling Peptide
EINECS	Contact for details

Quality Control

Our Akt/Skg Substrate Peptide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation, to ensure high batch-to-batch consistency and performance reliability for critical research applications. Certificates of Analysis (COA) detailing purity, sequence verification, and performance data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in aqueous buffers or DMSO
Biological Activity	Validated in standard kinase assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.