Description

Boc-Thionotyr(Tbu)-1-(6-Nitro)Benzotriazolide CAS NO 272442-17-8 is a specialized, high-purity peptide coupling reagent and protected amino acid derivative. This compound is critical for facilitating efficient and selective amide bond formation in complex peptide synthesis, particularly in solid-phase and solution-phase methodologies. It is an essential building block for pharmaceutical R&D and production, enabling the synthesis of novel therapeutic peptides and peptidomimetics with high fidelity.

Application

• Peptide Synthesis Reagent: Acts as a key coupling agent for the introduction of protected thionotyrosine residues into peptide chains.
• Pharmaceutical Intermediate: Serves as a critical building block in the research and development of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation Chemistry: Used in the site-specific modification of proteins and other biomolecules for drug delivery and diagnostic applications.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Academic & Industrial Research: A valuable tool for synthetic chemists in universities and contract research organizations (CROs) studying peptide structure-activity relationships.
• Synthesis of Modified Amino Acids: Used to prepare non-natural, sulfur-containing amino acid analogs for advanced material and biochemical studies.

Basic Information

Product Name	Boc-Thionotyr(Tbu)-1-(6-Nitro)Benzotriazolide
CAS No.	272442-17-8
Molecular Formula	C24H27N5O6S
Molecular Weight	513.57 g/mol
Synonyms	1-[(1,1-Dimethylethoxy)carbonyl]-4-(1,1-dimethylethyl) 2-[(6-nitro-1H-benzotriazol-1-yl)oxy]-L-thietyrosine; Boc-Thionotyr(OtBu)-ONb; Boc-L-Thionotyr(OtBu)-ONb; N-α-Boc-O-tert-butyl-L-thionotyrosine 6-nitrobenzotriazolide; tert-Butyl N-[(tert-butoxy)carbonyl]-S-[(6-nitro-1H-benzotriazol-1-yl)oxy]-L-cysteinate; Boc-Thionotyr(tBu)-ONb
EINECS	Contact for details

Quality Control

Our Boc-Thionotyr(Tbu)-1-(6-Nitro)Benzotriazolide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.