Description

1-Palmitoyl-2-Oleoyl-Sn-Glycero-3-Phospho-(1'-Rac-Glycerol) (Sodium Salt) is a high-purity, synthetic phospholipid widely used as a critical component in advanced formulation research. This compound, with CAS number 268550-95-4, serves as a fundamental building block for creating biomimetic membranes and stable lipid-based delivery systems. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced cosmetics industries who require precise and reliable lipid components for drug delivery, diagnostic assays, and model membrane studies.

Application

• Liposome & Nanoparticle Formulation: A key structural lipid for creating unilamellar vesicles (LUVs, SUVs) and solid lipid nanoparticles (SLNs) for targeted drug delivery.
• Biomimetic Membrane Models: Used to construct supported lipid bilayers (SLBs) and giant unilamellar vesicles (GUVs) for biophysical studies of membrane proteins and cellular processes.
• Pharmaceutical Excipient: Acts as a solubilizer and emulsifying agent in injectable formulations and topical preparations to enhance bioavailability.
• Diagnostic Reagent Manufacturing: Employed in the production of reagents for clinical diagnostics, including enzyme assays and immunoassays that require controlled membrane environments.
• Cell Culture & Transfection: A component of serum-free media supplements and non-viral transfection reagents to improve cell viability and gene delivery efficiency.
• Cosmetic Actives Carrier: Used in high-end skincare products to encapsulate and stabilize sensitive active ingredients like vitamins and antioxidants for improved dermal penetration.

Basic Information

Product Name	1-Palmitoyl-2-Oleoyl-Sn-Glycero-3-Phospho-(1'-Rac-Glycerol) (Sodium Salt)
CAS No.	268550-95-4
Molecular Formula	C41H78NaO10P
Molecular Weight	785.01 g/mol
Synonyms	POPG (Sodium Salt); 1-Palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) sodium salt; POPG-Na; PG(16:0/18:1) Sodium Salt; Phosphatidylglycerol (16:0/18:1) Sodium Salt; (2R)-2,3-Di(hexadecanoyloxy)propyl (9Z)-octadec-9-enoate hydrogen phosphate; Sodium 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol
EINECS	Contact for details

Quality Control

Our 1-Palmitoyl-2-Oleoyl-Sn-Glycero-3-Phospho-(1'-Rac-Glycerol) (Sodium Salt) is manufactured under strict quality management systems. Each batch is characterized using advanced analytical techniques including NMR and LC-MS to confirm structure and purity. We provide comprehensive Certificates of Analysis (COA) detailing purity, lipid profile, and critical impurities. Production can adhere to cGMP guidelines for pharmaceutical applications, ensuring traceability and consistency for critical research and development.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (argon or nitrogen). Under these conditions, the product is typically stable for at least 24 months. The material is hygroscopic (moisture-sensitive) and easily oxidized; allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Once opened, purge the container with inert gas and reseal immediately.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Lysophospholipid Content	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines
Water Content (KF)	≤ 2.0%
Fatty Acid Composition (GC)	Conforms to 16:0/18:1 profile
Heavy Metals (ICP-MS)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.