Description

N,N,N',N'-Tetramethyl-o-(n-Succinimidyl)Uronium Hexafluorophosphate is a high-purity peptide coupling reagent widely used in solid-phase peptide synthesis (SPPS). This compound matters because it offers superior reactivity and efficiency for forming amide bonds, minimizing racemization and enabling the synthesis of complex peptides. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences industries who require reliable and high-yielding reagents for peptide and protein chemistry.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key coupling agent for the efficient formation of amide bonds between amino acids.
• Solution-Phase Peptide Synthesis: For the synthesis of peptides and peptide fragments in solution.
• Bioconjugation: Facilitating the covalent attachment of peptides, proteins, or other molecules to surfaces, polymers, or biomolecules.
• Pharmaceutical Intermediate Production: In the synthesis of active pharmaceutical ingredients (APIs) that contain peptide sequences.
• Combinatorial Chemistry: Used in library synthesis for drug discovery and lead optimization.
• Proteomics Research: For the chemical synthesis of modified peptides used as standards or probes.
• Material Science: In the creation of peptide-based polymers and biomaterials.

Basic Information

Product Name	N,N,N',N'-Tetramethyl-o-(n-Succinimidyl)Uronium Hexafluorophosphate
CAS No.	265651-18-1
Molecular Formula	C11H19F6N5O3P
Molecular Weight	414.27 g/mol
Synonyms	HSTU; N,N,N',N'-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate; O-(N-Succinimidyl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1-[1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)dimethylaminomorpholino]uronium hexafluorophosphate; Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate; HSTU Reagent; Coupling Reagent HSTU; Uronium-based coupling agent
EINECS	Contact for details

Quality Control

Our N,N,N',N'-Tetramethyl-o-(n-Succinimidyl)Uronium Hexafluorophosphate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high performance in sensitive applications like peptide synthesis. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in acetonitrile, DMF, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.