Description

N6-Benzoyl-5'-o-(4,4'-Dimethoxytrityl)-3'-o-(2-Methoxyethyl)Adenosine is a key protected nucleoside derivative used as a critical building block in the synthesis of oligonucleotides. This compound is essential for researchers and manufacturers requiring high-purity intermediates for advanced nucleic acid chemistry, particularly in the development of antisense oligonucleotides, siRNAs, and aptamers. It is primarily utilized by the pharmaceutical, biotechnology, and life science research sectors where precise chemical modification and reliable supply chain integrity are paramount.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): Serves as a protected phosphoramidite precursor for the automated synthesis of modified DNA/RNA strands.
• Antisense & siRNA Therapeutics: A vital intermediate in the production of therapeutic oligonucleotides designed for gene silencing and targeted drug development.
• Research & Development: Used in academic and industrial R&D labs for exploring novel nucleic acid analogs and their biochemical properties.
• Diagnostic Probe Synthesis: Enables the creation of labeled and modified probes for advanced diagnostic assays and genomic testing.
• Aptamer Development: Facilitates the incorporation of specific modifications to enhance the stability and binding affinity of aptamers.
• Scale-Up cGMP Manufacturing: Suitable for use in controlled, large-scale production environments under current Good Manufacturing Practices (cGMP) for clinical-grade materials.

Basic Information

Product Name	N6-Benzoyl-5'-o-(4,4'-Dimethoxytrityl)-3'-o-(2-Methoxyethyl)Adenosine
CAS No.	256224-00-7
Molecular Formula	C41H41N5O8
Molecular Weight	731.80 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-3'-O-(2-methoxyethyl)adenosine; 3'-O-(2-Methoxyethyl)-5'-O-(4,4'-dimethoxytrityl)-N6-benzoyladenosine; DMTr-N6-Bz-3'-MOE-Adenosine; N6-Bz-5'-DMTr-3'-MOE-Ado; Protected 3'-MOE Adenosine Derivative; 3'-MOE-A(Bz)-5'-DMTr; Adenosine, N6-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-(2-methoxyethyl)-
EINECS	Contact for details

Quality Control

Our N6-Benzoyl-5'-o-(4,4'-Dimethoxytrityl)-3'-o-(2-Methoxyethyl)Adenosine is manufactured under strict quality control protocols to ensure it meets the high-purity standards required for sensitive oligonucleotide synthesis. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically assessed by HPLC, NMR, and mass spectrometry. We support compliance with ISO 9001 quality management systems and can provide material suitable for use in cGMP-regulated environments upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent decomposition. For long-term storage, desiccants are recommended.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.