Description

[(3R,3aS,6aR)-Hydroxyhexahydrofuro[2,3-b]furanyl Succinimidyl Carbonate is a high-purity, specialized chemical intermediate of significant importance in advanced pharmaceutical synthesis. Its core value lies in its role as a key building block for the production of complex nucleoside analogs and antiviral agents, enabling precise molecular construction. This compound is essential for research institutions and manufacturers in the pharmaceutical and biotechnology sectors who are developing next-generation therapeutics, particularly for antiviral applications.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex nucleoside and nucleotide analogs.
• Antiviral Drug Development: Used in the research and production of active pharmaceutical ingredients (APIs) for antiviral medications.
• ProTide Technology: Serves as a key reagent in the preparation of phosphoramidate prodrugs, enhancing drug delivery and efficacy.
• Bioconjugation: Utilized in the modification of biomolecules due to its reactive succinimidyl carbonate group.
• Organic Synthesis Research: Employed in academic and industrial R&D for constructing sophisticated heterocyclic frameworks.
• Process Chemistry: Integrated into scalable manufacturing routes for high-value specialty chemicals.

Basic Information

Product Name	[(3R,3aS,6aR)-Hydroxyhexahydrofuro[2,3-b]furanyl Succinimidyl Carbonate
CAS No.	253265-97-3
Molecular Formula	C11H13NO8
Molecular Weight	287.22 g/mol
Synonyms	(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl (2,5-dioxopyrrolidin-1-yl) carbonate; 1-{[(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl]oxy}carbonyloxy-2,5-pyrrolidinedione; 2,5-Dioxopyrrolidin-1-yl (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl carbonate; Isopropylidene Ribose Succinimidyl Carbonate; Ribose carbonate NHS ester; ProTide Intermediate; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our [(3R,3aS,6aR)-Hydroxyhexahydrofuro[2,3-b]furanyl Succinimidyl Carbonate is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccated environment after opening.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.