Description

Biotin-Peg3-Propionic Acid CAS NO 252881-76-8 is a high-purity, heterobifunctional polyethylene glycol (PEG) linker featuring a biotin moiety and a carboxylic acid terminus. This compound is essential for creating stable, site-specific conjugations in bioconjugation and drug delivery applications, enabling the attachment of biomolecules to surfaces, carriers, or other functional groups. It is primarily needed by researchers and manufacturers in the pharmaceutical, diagnostic, and life science industries for developing targeted therapeutics, assay components, and advanced biomaterials.

Application

• Bioconjugation Reagent: For the site-specific labeling of proteins, antibodies, peptides, and oligonucleotides with biotin tags.
• ADC (Antibody-Drug Conjugate) Development: Serves as a cleavable or non-cleavable linker to connect cytotoxic payloads to targeting antibodies.
• Diagnostic Assay Development: Used to functionalize surfaces (e.g., sensor chips, microplates) for immobilizing biomolecules in ELISA, SPR, and other biosensing platforms.
• Drug Delivery Systems: Facilitates the creation of PEGylated nanoparticles and liposomes for enhanced drug solubility, stability, and targeted delivery.
• Affinity Chromatography: Immobilized onto solid supports to create resins for the purification of streptavidin/avidin-tagged proteins.
• Proteomics & Cell Biology: A key tool for pull-down assays, protein interaction studies, and cell surface labeling.
• Material Science: Used to modify biomaterial surfaces to promote specific cellular interactions or reduce fouling.

Basic Information

Product Name	Biotin-Peg3-Propionic Acid
CAS No.	252881-76-8
Molecular Formula	C₂₃H₄₁N₃O₈S
Molecular Weight	519.65 g/mol
Synonyms	Biotin-PEG3-CH2CH2COOH; Biotin-PEG3-Propanoic Acid; Biotin-PEG3-C2-Acid; 5-[(3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-N-[2-[2-(2-carboxyethoxy)ethoxy]ethyl]pentanamide; Biotin-amido-PEG3-propionic acid; Biotin-PEG(3)-acid; Biotin-PEG3-CA; Biotinylated PEG3 acid
EINECS	Contact for details

Quality Control

Our Biotin-Peg3-Propionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for critical research and GMP-grade applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.