Description

Dotap Mesylate, 98 CAS NO 252769-92-9 is a high-purity cationic lipid widely recognized for its critical role in the formulation of lipid nanoparticles (LNPs) and liposomes. This compound is essential for enabling efficient nucleic acid delivery, a cornerstone technology for modern gene therapy and vaccine development. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and CROs focused on advancing non-viral transfection and drug delivery systems for mRNA, siRNA, and DNA.

Application

• Primary Component in Lipid Nanoparticles (LNPs) for mRNA vaccine and therapeutic delivery.
• Cationic Liposome Formulation for in vitro and in vivo transfection of nucleic acids (DNA, siRNA, miRNA).
• Gene Therapy Research as a key transfection reagent for non-viral vector development.
• Cell Culture & Biotechnology for enhancing cellular uptake of macromolecules.
• Drug Delivery System Development for creating targeted and sustained-release formulations.
• Basic Research in membrane biophysics and lipid bilayer studies.

Basic Information

Product Name	Dotap Mesylate, 98
CAS No.	252769-92-9
Molecular Formula	C42H80N2O4 • CH4O3S
Molecular Weight	771.16 g/mol
Synonyms	1,2-Dioleoyl-3-trimethylammonium-propane (chloride salt) methanesulfonate; DOTAP Methanesulfonate; N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-trimethylammonium methylsulfonate; DOTAP-MS; CL-1-69; Cationic lipid DOTAP mesylate; N-(2,3-Dioleoyloxy-1-propyl)trimethylammonium methanesulfonate
EINECS	Contact for details

Quality Control

Our Dotap Mesylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive biopharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality protocols are designed to meet the stringent requirements of research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm
Bacterial Endotoxins	< 10 EU/mg (if specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.