Description

Dmt-2μ-o-Me-Rg(Ib) Amidite is a specialized phosphoramidite monomer, a critical building block in the automated solid-phase synthesis of oligonucleotides. This high-purity reagent is essential for the precise and efficient incorporation of modified nucleosides into DNA and RNA sequences. It is primarily required by research institutions, diagnostic developers, and pharmaceutical companies engaged in advanced applications such as antisense therapy, siRNA development, and molecular diagnostics.

Application

• Oligonucleotide Synthesis: As a key phosphoramidite monomer for the automated synthesis of modified DNA and RNA strands.
• Therapeutic Oligonucleotide R&D: For the development of antisense oligonucleotides (ASOs), small interfering RNA (siRNA), and aptamers with enhanced properties.
• Diagnostic Probe Manufacture: In the production of labeled probes for PCR, microarrays, and next-generation sequencing (NGS) applications.
• Basic Biochemical Research: For studying nucleic acid structure, function, and protein-nucleic acid interactions using site-specifically modified oligonucleotides.
• Synthesis of Primers and Linkers: For creating custom primers and functionalized linkers used in various molecular biology techniques.

Basic Information

Product Name	Dmt-2μ-o-Me-Rg(Ib) Amidite
CAS No.	251647-55-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-O-methylriboguanosine, 3'-[(2-Cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 2'-O-Methyl-G Phosphoramidite (DMT protected); 2'-O-Me-rG Phosphoramidite; Guanosine, 2'-O-methyl-, 3'-(2-cyanoethyl diisopropylphosphoramidite), 5'-O-(4,4'-dimethoxytrityl) derivative; DMT-2'-O-Methyl-Guanosine Phosphoramidite
EINECS	Contact for details

Quality Control

Every batch of Dmt-2μ-o-Me-Rg(Ib) Amidite is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and 31P NMR, to ensure high purity and consistency suitable for sensitive oligonucleotide synthesis. Certificates of Analysis (COA) with full specification data are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C ± 5°C under an inert atmosphere (argon or nitrogen) in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Moisture Content (KF)	≤ 1.0%
Solubility	Clear, colorless solution in anhydrous acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.