Description

Fmoc-L-Allo-Isoleucine CAS NO 251316-98-0 is a protected, non-proteinogenic amino acid derivative essential for solid-phase peptide synthesis (SPPS). This high-purity building block is critical for researchers and manufacturers developing complex peptides and peptidomimetics with precise stereochemistry. It is primarily utilized by the pharmaceutical, biotechnology, and academic research sectors for drug discovery, API development, and biochemical studies.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the sequential assembly of custom peptide sequences.
• Pharmaceutical Research: Incorporation into novel therapeutic peptides and peptidomimetic drug candidates targeting various diseases.
• Bioconjugation: Used in the synthesis of peptide tags, linkers, and carriers for antibody-drug conjugates (ADCs) and diagnostic probes.
• Material Science: A building block for engineered biomaterials, peptide-based polymers, and surface coatings.
• Academic & Contract Research: Fundamental research tool for studying protein structure-function relationships, enzyme substrates, and inhibitors.

Basic Information

Product Name	Fmoc-L-Allo-Isoleucine
CAS No.	251316-98-0
Molecular Formula	C21H23NO4
Molecular Weight	353.41 g/mol
Synonyms	Fmoc-L-allo-Ile; Fmoc-allo-isoleucine; (2S,3S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-methylpentanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-allo-isoleucine; N-Fmoc-L-allo-isoleucine; Fmoc-L-α-amino-β-methylvaleric acid (allo form); N-(9-Fluorenylmethoxycarbonyl)-L-allo-isoleucine; Fmoc-allo-Ile-OH
EINECS	Contact for details

Quality Control

Our Fmoc-L-Allo-Isoleucine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and MS. We adhere to relevant industry standards for fine chemicals and pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.