Description

Pegaptanib Octasodium is a chemically synthesized oligonucleotide aptamer, specifically designed as a selective antagonist of vascular endothelial growth factor (VEGF165). This high-purity active pharmaceutical ingredient (API) is critical for developing targeted ophthalmic therapeutics. It is primarily required by pharmaceutical manufacturers and advanced research institutions focused on treatments for neovascular (wet) age-related macular degeneration (AMD) and other VEGF-mediated ocular conditions.

Application

• Ophthalmic Pharmaceutical Formulations: Primary API for intravitreal injections targeting wet age-related macular degeneration (AMD).
• Angiogenesis Inhibition Research: Key tool compound for studying VEGF165-specific signaling pathways and anti-angiogenic mechanisms.
• Drug Delivery System Development: Used in research for novel sustained-release formulations and implantable devices for ocular use.
• Biosimilar & Generic Drug Development: Serves as the reference standard for analytical method development and regulatory filing.
• Preclinical & Clinical Trial Material: Supplied as GMP-grade material for non-clinical studies and clinical batch manufacturing.

Basic Information

Product Name	Pegaptanib Octasodium
CAS No.	250689-71-5
Molecular Formula	C294H342F13N107Na8O188P28
Molecular Weight	~ 50,000 Da (Contact for exact specification)
Synonyms	Pegaptanib Sodium; Macugen (Brand Name); Anti-VEGF Oligonucleotide; VEGF Aptamer; ARC127; EYE001; NU172; Oligonucleotide NX 1838; 5'-d(G*G*G*A*A*C*C*G*U*U*C*A*U*C*C*C*U*C*A*G)-3' (Sequence with modifications); (2'-Deoxy-2'-fluoro)C,G ribonucleotide residues
EINECS	Contact for details

Quality Control

Our Pegaptanib Octasodium is manufactured under strict quality systems. Each batch is tested to ensure it meets stringent specifications for identity, purity, potency, and impurities, suitable for pharmaceutical development. We provide comprehensive Certificates of Analysis (COA) with data from advanced analytical techniques, supporting regulatory submissions. Quality standards align with ICH guidelines and current Good Manufacturing Practice (cGMP) principles.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0% (on anhydrous basis)
Purity (Related Substances, HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH Q3C limits
Biological Activity (Cell-based Assay)	Contact for details
Endotoxin (LAL)	< 10 EU/mg
Sterility (for sterile grade)	Sterile (where specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.