Description

L-Glutamic Acid, n-[(1,1-Dimethylethoxy)Carbonyl]-, 1,5-Bis(2,5-Dioxo-1-Pyrrolidinyl) Ester is a specialized, high-purity chemical building block designed for advanced organic synthesis. This compound is critical for researchers and manufacturers requiring precise, site-specific conjugation and cross-linking in complex molecular architectures. It is primarily utilized in the development of novel pharmaceuticals, sophisticated peptide synthesis, and advanced materials science where controlled reactivity and high selectivity are paramount.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of complex active pharmaceutical ingredients (APIs) and prodrugs.
• Peptide Synthesis & Modification: Used as a protected glutamic acid derivative for the controlled introduction of glutamyl residues or as a cross-linking agent in solid-phase peptide synthesis (SPPS).
• Bioconjugation & Linker Chemistry: Serves as a heterobifunctional cross-linker for coupling biomolecules (e.g., proteins, antibodies) to drugs, dyes, or solid surfaces via its active ester groups.
• Polymer & Materials Science: Employed in the synthesis of functionalized polymers, dendrimers, and smart materials requiring specific, reactive end-groups.
• Proteomics Research: Utilized in chemical proteomics for labeling and studying protein-protein interactions and post-translational modifications.
• Diagnostic Reagent Development: Acts as a component in the creation of sensitive assay components and diagnostic conjugates.

Basic Information

Product Name	L-Glutamic Acid, n-[(1,1-Dimethylethoxy)Carbonyl]-, 1,5-Bis(2,5-Dioxo-1-Pyrrolidinyl) Ester
CAS No.	246234-73-1
Molecular Formula	C19H25N3O9
Molecular Weight	439.42 g/mol
Synonyms	Boc-Glu(OSu)-OSu; N-Boc-L-glutamic acid α,γ-bis(N-hydroxysuccinimide ester); Nα-Boc-L-glutamic acid 1,5-bis(succinimidyl) ester; N-tert-Butoxycarbonyl-L-glutamic acid α,γ-bis(succinimidyl) ester; Boc-Glu-OSu2; Boc-L-glutamic acid bis(N-succinimidyl) ester; Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 1,5-bis(2,5-dioxo-1-pyrrolidinyl) ester, L-
EINECS	Contact for details

Quality Control

Our L-Glutamic Acid, n-[(1,1-Dimethylethoxy)Carbonyl]-, 1,5-Bis(2,5-Dioxo-1-Pyrrolidinyl) Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR), to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation [α]D20	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.