Description

H-Arg-Gln-Arg-Arg-Amc Trifluoroacetate Salt is a synthetic peptide substrate designed for high-precision biochemical research and diagnostic applications. This compound is critical for studying and quantifying the activity of specific proteolytic enzymes, particularly furin and related proprotein convertases. It is an essential tool for researchers and developers in pharmaceutical discovery, molecular biology, and clinical diagnostics who require reliable and sensitive assay components.

Application

• Enzyme Activity Assays: Primary substrate for the fluorometric or colorimetric detection and quantification of furin and PC (Proprotein Convertase) enzyme activity.
• Drug Discovery Screening: Used in high-throughput screening (HTS) platforms to identify and characterize potential inhibitors of furin, a target in viral infections, cancer, and other diseases.
• Biochemical Research: Essential for kinetic studies, enzyme characterization, and understanding protease substrate specificity in academic and industrial R&D laboratories.
• Diagnostic Kit Development: Incorporated as a key reagent in the development of diagnostic assays for conditions involving dysregulated protease activity.
• Virology Studies: Applied in research on viral pathogenesis, as furin-mediated cleavage is crucial for the activation of envelope glycoproteins in viruses like influenza and SARS-CoV-2.

Basic Information

Product Name	H-Arg-Gln-Arg-Arg-Amc Trifluoroacetate Salt
CAS No.	243466-39-9
Molecular Formula	C30H53N15O7 • xC2HF3O2
Molecular Weight	~759.8 g/mol (free base)
Synonyms	Arg-Gln-Arg-Arg-AMC TFA Salt; H-Arg-Gln-Arg-Arg-AMC; Boc-RVRR-AMC (related precursor); Furin Substrate; Pyr-Arg-Thr-Lys-Arg-AMC (alternative sequence); Proprotein Convertase Substrate; Peptide Substrate for Furin; RQRR-AMC; AMC-labeled Furin Substrate; Fluorogenic Peptide Substrate 243466-39-9
EINECS	Contact for details

Quality Control

Every batch of H-Arg-Gln-Arg-Arg-Amc Trifluoroacetate Salt is manufactured and tested under strict quality management systems. We guarantee high purity and batch-to-batch consistency suitable for sensitive research applications. Certificates of Analysis (COA) detailing purity, identity, and performance in standard assays are provided with each shipment to ensure compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 70%
Functional Activity	Conforms to reference standard in furin assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.