Description

Tosedostat CAS NO 238750-77-1 is a potent and selective inhibitor of aminopeptidases, specifically targeting the M1 family of metalloenzymes. This mechanism of action makes it a compound of significant interest for research into novel therapeutic strategies. It is primarily utilized in pharmaceutical research and development, particularly in the fields of oncology and immunology. Researchers and developers rely on this high-purity compound for preclinical studies and as a critical reference standard.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel anticancer therapies.
• Oncology Studies: Used in preclinical research to investigate its efficacy against various cancer cell lines, leveraging its role as an aminopeptidase inhibitor to disrupt tumor cell metabolism and proliferation.
• Biochemical Assay Development: Employed as a specific inhibitor in enzymatic assays to study the function and inhibition kinetics of aminopeptidases, aiding in target validation.
• Immunology Research: Investigated for potential immunomodulatory effects, given the role of specific aminopeptidases in antigen processing and immune response regulation.
• Academic & Institutional Research: Utilized in university and research institute laboratories for fundamental studies in cell biology, enzymology, and drug discovery pathways.
• Process Chemistry & Scale-up: Acts as a critical building block for process chemists during the optimization and scale-up of synthetic routes for potential drug candidates.

Basic Information

Product Name	Tosedostat
CAS No.	238750-77-1
Molecular Formula	C₂₀H₂₃ClN₄O₄
Molecular Weight	418.87 g/mol
Synonyms	CHR-2797; (2S)-2-[[(2S)-2-Acetamido-4-methylpentanoyl]amino]-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]pentanediamide; Tosedostat Hydrochloride (salt form reference); Aminopeptidase Inhibitor CHR-2797; (2S)-2-[[(2S)-2-Acetamido-4-methylpentanoyl]amino]-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]pentanediamide
EINECS	Contact for details

Quality Control

Every batch of Tosedostat is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the identity, purity, and consistency of the product for critical research applications. Certificates of Analysis (COA) with detailed results from HPLC, NMR, and MS are available upon request. Our quality commitment supports compliance with cGMP guidelines for API intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.