Description

Fmoc-Asp-Amc CAS NO 238084-15-6 is a specialized, protected amino acid derivative widely used in solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring high-purity building blocks for constructing complex peptides and peptidomimetics. It is an essential raw material for pharmaceutical R&D, particularly in the development of protease substrates, inhibitors, and fluorescent probes for biochemical assays.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key Fmoc-protected aspartic acid derivative with the Amc (7-amino-4-methylcoumarin) fluorophore for constructing C-terminal labeled peptides.
• Protease Assay Development: Used to synthesize fluorogenic peptide substrates for detecting and quantifying the activity of various proteases, including caspases, cathepsins, and other hydrolases.
• Drug Discovery & Medicinal Chemistry: Acts as a crucial intermediate in the research and development of peptide-based therapeutics and diagnostic agents.
• Biochemical Research: Employed in the study of enzyme kinetics, protein-protein interactions, and intracellular signaling pathways using fluorescence-based techniques.
• High-Throughput Screening (HTS): Integral for creating sensitive fluorescent probes used in automated screening platforms to identify potential drug candidates.

Basic Information

Product Name	Fmoc-Asp-Amc
CAS No.	238084-15-6
Molecular Formula	C30H26N2O8
Molecular Weight	542.54 g/mol
Synonyms	Fmoc-Asp(AMC); Fmoc-L-Aspartic acid β-(7-amino-4-methylcoumarin); N-(9-Fluorenylmethoxycarbonyl)-L-aspartic acid 4-methyl-7-coumarylamide; Fmoc-Asp-AMC; Fmoc-Asp-7-amido-4-methylcoumarin; Nα-Fmoc-L-aspartic acid 4-methylcoumarin-7-ylamide; Fmoc-Aspartic acid 7-amido-4-methylcoumarin; Fmoc-Asp-AMC-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Asp-Amc is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and advanced biochemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -15°C. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Conforms to ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.