Description

1,2-Dioleoyl-Sn-Glycero-3-Phospho[n-(4-Carboxybutanoyl)Ethanolamine] is a high-purity, functionalized phospholipid essential for advanced pharmaceutical and biotechnological research. This compound is a critical building block for creating targeted drug delivery systems, particularly in the formulation of lipid nanoparticles (LNPs) for mRNA vaccines and therapeutics. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require precise and reliable components for complex nano-formulations.

Application

• Lipid Nanoparticle (LNP) Formulation: A key functional excipient for constructing stable, targeted LNPs used in mRNA vaccine and therapeutic delivery.
• Targeted Drug Delivery Systems: Enables surface functionalization of liposomes and other nanocarriers for cell-specific targeting via its carboxyl group.
• Bioconjugation & Ligand Attachment: The terminal carboxylic acid moiety serves as a convenient handle for covalent attachment of targeting peptides, antibodies, or other biomolecules.
• Pharmaceutical Research: Used in preclinical and clinical development of novel nanomedicines for cancer therapy, gene therapy, and other specialized treatments.
• Biomimetic Membrane Studies: Employed in model membrane systems to study membrane-protein interactions and cellular uptake mechanisms.
• Diagnostic Agent Carrier: Facilitates the encapsulation and delivery of imaging contrast agents for diagnostic purposes.

Basic Information

Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phospho[n-(4-Carboxybutanoyl)Ethanolamine]
CAS No.	228706-30-7
Molecular Formula	C48H88NO10P
Molecular Weight	870.19 g/mol
Synonyms	18:1 DOPE-N-Carboxyglutaryl; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-(carboxyglutaryl); DOPE-N-Carboxyglutaryl; DOPE-N-CG; N-Carboxyglutaryl-1,2-dioleoyl-sn-glycero-3-phosphoethanolamine; Phospholipid-PEG-COOH (variant); Functionalized DOPE; Carboxylated DOPE
EINECS	Contact for details

Quality Control

Our 1,2-Dioleoyl-Sn-Glycero-3-Phospho[n-(4-Carboxybutanoyl)Ethanolamine] is manufactured under strict quality systems suitable for pharmaceutical research. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with exacting specifications. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Solubility	Soluble in chloroform, ethanol; forms dispersions in aqueous buffers
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.