Description

(n-Succinimidyloxycarbonylmethyl)Tris(2,4,6-Trimethoxyphenyl)Phosphonium Bromide is a highly reactive, water-soluble phosphonium salt primarily used as a specialized coupling reagent in peptide synthesis and bioconjugation chemistry. Its core value lies in its ability to efficiently activate carboxylic acids under mild conditions, facilitating the formation of amide bonds with primary amines. This makes it an essential reagent for researchers and manufacturers in pharmaceutical development, proteomics, and the production of antibody-drug conjugates (ADCs). The compound, identified by CAS No. 226409-58-1, is critical for applications requiring high coupling efficiency and minimal racemization.

Application

• Peptide Synthesis: As a key coupling reagent (often compared to HBTU or HATU) for the solid-phase and solution-phase synthesis of peptides and peptidomimetics.
• Bioconjugation & ADC Manufacturing: For the site-specific conjugation of cytotoxic drugs, fluorophores, or other payloads to antibodies, proteins, or oligonucleotides.
• Proteomics Research: Used in chemical proteomics for labeling and enriching proteins, facilitating activity-based protein profiling (ABPP).
• Material Science Functionalization: To introduce active ester groups onto surfaces, polymers, or nanoparticles for subsequent biomolecule immobilization.
• Cross-linking Agent: Employed in the preparation of cross-linked biomaterials or hydrogels for tissue engineering and drug delivery systems.
• Intermediate for Specialty Chemicals: Serves as a building block in the synthesis of more complex phosphonium-based catalysts or ionic liquids.

Basic Information

Product Name	(n-Succinimidyloxycarbonylmethyl)Tris(2,4,6-Trimethoxyphenyl)Phosphonium Bromide
CAS No.	226409-58-1
Molecular Formula	C34H39BrNO11P
Molecular Weight	772.54 g/mol
Synonyms	Bromotris(2,4,6-trimethoxyphenyl)phosphonium (2,5-dioxopyrrolidin-1-yl)acetate; (2,5-Dioxopyrrolidin-1-yl)oxycarbonylmethyltris(2,4,6-trimethoxyphenyl)phosphonium bromide; TSTU Phosphonium Salt; N-Hydroxysuccinimide Phosphonium Salt; Suc-OSu Phosphonium Bromide; Coupling Reagent TSTU; (N-Succinimidyloxycarbonylmethyl)tris(2,4,6-trimethoxyphenyl)phosphonium bromide
EINECS	Contact for details

Quality Control

Our (n-Succinimidyloxycarbonylmethyl)Tris(2,4,6-Trimethoxyphenyl)Phosphonium Bromide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high reactivity. Each lot is characterized by advanced analytical techniques to confirm identity, purity, and suitability for sensitive bioconjugation applications. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), water content (KF), and residual solvents are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant (e.g., in a sealed bag with silica gel) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and hydrolysis. For long-term storage, consider storing under an inert atmosphere (argon or nitrogen).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.