Description

Ripasudil CAS NO 223645-67-8 is a selective Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor with significant therapeutic potential. This compound is of critical importance for its role in modulating cellular processes related to cytoskeletal dynamics and intraocular pressure. It is primarily required by pharmaceutical research and development organizations, as well as manufacturers of active pharmaceutical ingredients (APIs), for the development of ophthalmic treatments.

Application

• Primary Pharmaceutical Ingredient: Serves as the key active pharmaceutical ingredient (API) in the formulation of ophthalmic solutions for treating glaucoma and ocular hypertension.
• Clinical Research & Development: Used as a reference standard and investigational compound in preclinical and clinical studies targeting Rho-kinase pathways.
• Mechanistic Studies: Employed in biochemical and pharmacological research to study the role of ROCK inhibition in vascular smooth muscle contraction, cell motility, and neuronal growth.
• Drug Discovery: Acts as a lead compound or pharmacophore model for the design and synthesis of novel ROCK inhibitors for various therapeutic areas beyond ophthalmology.
• Analytical Standard: Utilized as a high-purity certified reference material (CRM) for quality control and analytical method development (e.g., HPLC, LC-MS) in pharmaceutical laboratories.

Basic Information

Product Name	Ripasudil
CAS No.	223645-67-8
Molecular Formula	C₁₇H₁₄FN₃O₂S
Molecular Weight	343.38 g/mol
Synonyms	K-115; Ripasudil Hydrochloride; K-115 (Hydrochloride); 4-Fluoro-5-[(2-methyl-1H-imidazo[1,2-b]pyridazin-6-yl)amino]-2-(1H-pyrrolo[2,3-b]pyridin-3-yl)benzonitrile; 4-Fluoro-5-[(2-methylimidazo[1,2-b]pyridazin-6-yl)amino]-2-(7-azaindol-3-yl)benzonitrile; Glanatec; IZERVAY (brand name for ophthalmic solution)
EINECS	Contact for details

Quality Control

Our Ripasudil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. Specifications typically align with pharmacopeial guidelines for identification, purity, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results for assay, related substances, residual solvents, and other critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.