Description

Ripasudil Hydrochloride CAS NO 223644-02-8 is a selective Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor, specifically developed for ophthalmic applications. This high-purity active pharmaceutical ingredient (API) is critical for the formulation of advanced therapeutics targeting ocular hypertension and glaucoma. It is primarily required by pharmaceutical manufacturers and research institutions engaged in developing and producing innovative eye care solutions.

Application

• Primary API for the formulation of ophthalmic solutions targeting glaucoma and ocular hypertension.
• Key ingredient in ophthalmic drug development for research into Rho-kinase inhibition pathways.
• Used in preclinical and clinical studies for novel topical eye drop formulations.
• Reference standard for analytical method development and quality control in pharmaceutical laboratories.
• Starting material for the synthesis of related derivatives in medicinal chemistry research.
• Essential component in the manufacturing of finished dosage forms under GMP conditions.

Basic Information

Item	Detail
Product Name	Ripasudil Hydrochloride
CAS No.	223644-02-8
Molecular Formula	C₂₇H₂₈N₄O₃S·HCl
Molecular Weight	517.06 g/mol
Synonyms	K-115; Ripasudil HCl; 4-Fluoro-5-[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl-isoquinoline Hydrochloride; (S)-4-Fluoro-5-(2-methyl-1,4-diazepane-1-sulfonyl)isoquinoline Hydrochloride; K115 Hydrochloride; GLANATEC (Brand Name); Rho-Kinase Inhibitor K-115; UNII-9F8N0N4Z1P
EINECS	Contact for details

Quality Control

Our Ripasudil Hydrochloride is manufactured under strict quality systems suitable for pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods, to ensure compliance with ICH guidelines and internal specifications. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.