Description

2'-(n-Methylanthraniloyl)Guanosine 3',5'-Cyclicmonophosphate, Sodium Salt is a high-purity, fluorescently labeled analog of cyclic GMP (cGMP) designed for advanced biochemical research. This compound serves as a critical tool for the sensitive and specific detection of cGMP-binding proteins and the study of intracellular signaling pathways. It is primarily utilized by researchers and scientists in the fields of pharmaceutical development, molecular biology, and cellular physiology for applications such as high-throughput screening and enzyme activity assays.

Application

• Biochemical Research Probe: Used as a fluorescent tracer in competitive binding assays to study cGMP-dependent protein kinases (PKG), phosphodiesterases (PDEs), and ion channels.
• Drug Discovery & High-Throughput Screening (HTS): Enables the identification and characterization of novel modulators (agonists/antagonists) of cGMP-signaling pathways in pharmaceutical R&D.
• Cellular Signaling Studies: Facilitates the investigation of nitric oxide (NO) and natriuretic peptide signaling cascades within live cells or tissue extracts.
• Diagnostic Assay Development: Acts as a key component in developing sensitive diagnostic kits for measuring cGMP levels or related enzyme activities in clinical research settings.
• Enzyme Kinetics & Characterization: Employed to determine the kinetic parameters (Km, Vmax) and inhibition profiles of cGMP-metabolizing enzymes.

Basic Information

Product Name	2'-(n-Methylanthraniloyl)Guanosine 3',5'-Cyclicmonophosphate, Sodium Salt
CAS No.	221905-46-0
Molecular Formula	C23H22N7O9P • xNa
Molecular Weight	Approx. 609.4 g/mol (free acid)
Synonyms	2'-O-(N-Methylanthraniloyl)guanosine 3',5'-cyclic monophosphate sodium salt; MANT-cGMP, Sodium Salt; Fluorescent cGMP analog; 2'-(N-Methylanthraniloyl)-cGMP Na+; cGMP, 2'-(N-methylanthraniloyl)-, sodium salt; 2'-MANT-cGMP; 2'-(N-Methyl-2-anthraniloyl)-cGMP
EINECS	Contact for details

Quality Control

Our 2'-(n-Methylanthraniloyl)Guanosine 3',5'-Cyclicmonophosphate, Sodium Salt is manufactured under strict quality protocols suitable for research use. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and spectroscopic methods for identity confirmation. Certificates of Analysis (COA) detailing batch-specific results for purity, identity, and moisture content are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Yellow to orange lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (UV/VIS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.