Description

2,3-Di-Nor-8-Isoprostaglandin F2A is a specialized isoprostane analog, a key biomarker and reference standard for oxidative stress research. This high-purity compound is critical for the accurate quantification and study of lipid peroxidation in biological systems. It is primarily utilized by pharmaceutical R&D laboratories, clinical research organizations, and academic institutions focused on cardiovascular, neurodegenerative, and inflammatory disease mechanisms.

Application

• Biomarker Reference Standard: Primary application as a certified reference material for the precise calibration of analytical methods (LC-MS/MS, GC-MS) measuring endogenous isoprostane levels.
• Oxidative Stress Research: Essential tool for investigating the role of lipid peroxidation in disease models, including atherosclerosis, Alzheimer's disease, and diabetes.
• Pharmacological Studies: Used to evaluate the efficacy of antioxidant therapies and novel compounds designed to mitigate oxidative damage.
• Clinical Assay Development: Serves as a critical component in developing and validating diagnostic assays for oxidative stress status in patient samples.
• Toxicology & Safety Assessment: Employed in studies assessing drug-induced oxidative stress and environmental toxin exposure.
• Nutritional Science Research: Used to measure the impact of diets, supplements, and nutraceuticals on biomarkers of oxidative stress.

Basic Information

Product Name	2,3-Di-Nor-8-Isoprostaglandin F2A
CAS No.	221664-05-7
Molecular Formula	C18H30O5
Molecular Weight	326.43 g/mol
Synonyms	2,3-Dinor-8-iso-PGF2α; 8-iso-2,3-Dinor Prostaglandin F2α; 2,3-Dinor-8-iso-Prostaglandin F2α; 15-F2t-IsoP (2,3-dinor); 8-iso-PGF2α (2,3-dinor); (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]cyclopentyl]hept-5-enoic Acid; DN-8-iso-PGF2α
EINECS	Contact for details

Quality Control

Every batch of 2,3-Di-Nor-8-Isoprostaglandin F2A is manufactured and analyzed under strict quality management systems. We guarantee high chemical purity and stability, with comprehensive characterization using NMR, MS, and HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and conformance to specifications. Our quality commitment ensures reliable and reproducible results for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep the container in a dry, cool, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 1.0 %
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.