Description

17Beta-Estradiol-2,4,16,16,17-D5 is a high-purity, deuterium-labeled internal standard essential for accurate quantitative analysis in mass spectrometry. This compound is critical for ensuring data integrity and regulatory compliance in sensitive analytical workflows. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and diagnostic manufacturers for applications in bioanalytical method development, pharmacokinetic studies, and clinical research.

Application

• Internal Standard for LC-MS/MS quantification of endogenous estradiol in biological matrices (plasma, serum, urine).
• Bioanalytical method development and validation for pharmacokinetic (PK) and pharmacodynamic (PD) studies.
• Clinical research and diagnostic assay development for hormonal disorder analysis.
• Metabolomics and steroidomics research to study endocrine pathways.
• Quality control and reference standard in pharmaceutical manufacturing of hormone-based therapies.
• Forensic analysis for the detection and quantification of steroid hormones.

Basic Information

Product Name	17Beta-Estradiol-2,4,16,16,17-D5
CAS No.	221093-45-4
Molecular Formula	C18H19D5O2
Molecular Weight	275.41 g/mol
Synonyms	Estradiol-d5; [2,4,16,16,17-2H5]-Estradiol; Deuterated Estradiol; 17β-Estradiol-2,4,16,16,17-d5; E2-d5; (17β)-Estra-1,3,5(10)-triene-3,17-diol-2,4,16,16,17-d5; 1,3,5(10)-Estratrien-3,17β-diol-2,4,16,16,17-d5
EINECS	Contact for details

Quality Control

Every batch of 17Beta-Estradiol-2,4,16,16,17-D5 is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We guarantee high chemical and isotopic purity to meet the exacting standards of analytical and research applications. Certificates of Analysis (COA) detailing specifications such as HPLC purity, isotopic enrichment, and residual solvent levels are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity	≥ 95.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.