Description

Dansyl-Neca is a high-purity, fluorescently labeled chemical probe specifically designed for adenosine receptor research. This compound is critical for advanced pharmacological studies, enabling precise visualization and quantification of receptor binding and activity. It is primarily utilized by research scientists and pharmaceutical developers in the fields of neuroscience, cardiology, and immunology for high-throughput screening and mechanistic investigations.

Application

• Adenosine Receptor Research: Acts as a potent and selective fluorescent agonist for A2A and A3 adenosine receptor subtypes.
• High-Throughput Screening (HTS): Enables fluorescence-based assays for drug discovery programs targeting adenosine pathways.
• Cellular Imaging: Used in fluorescence microscopy to study receptor localization, internalization, and trafficking in live cells.
• Binding Assays: Serves as a tracer in competitive binding studies to determine the affinity of novel compounds.
• Signal Transduction Studies: Facilitates the investigation of downstream cAMP signaling and other second messenger systems.
• Biochemical Pharmacology: A key tool for characterizing receptor-ligand interactions and allosteric modulation.

Basic Information

Product Name	Dansyl-Neca
CAS No.	219982-12-4
Molecular Formula	C24H29N7O5S
Molecular Weight	527.60 g/mol
Synonyms	5'-(N-Ethylcarboxamido)-N6-(5-dimethylaminonaphthalene-1-sulfonyl)adenosine; Dansyl-NECA; N6-Dansyl-NECA; 2-[[6-[[(2R,3R,4S,5R)-5-(Ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]amino]purin-2-yl]amino]-N,N-dimethylnaphthalene-1-sulfonamide; Fluorescent NECA derivative; Adenosine A2A/A3 receptor fluorescent agonist
EINECS	Contact for details

Quality Control

Every batch of Dansyl-Neca is manufactured and analyzed under strict quality protocols to ensure exceptional purity and consistent biological activity, suitable for sensitive research applications. Our quality assurance includes comprehensive analytical testing via HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and assay results is provided with each shipment to guarantee traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, keep the primary container sealed within a secondary, light-proof barrier.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.