Description

(6α,11β,16α,17α)-6,9-Difluoro-11-Hydroxy-16-Methyl-Spiro[Androsta-1,4-Diene-17,5'-[1,3]Oxathiolane]-2',3,4'-Trione is a high-purity synthetic steroid derivative characterized by its complex spirocyclic structure. This compound is of significant value as a key pharmaceutical intermediate in the research and development of novel therapeutic agents. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in advanced steroid chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel corticosteroid analogs and other biologically active steroid molecules.
• Drug Discovery & Development: Used in medicinal chemistry research for structure-activity relationship (SAR) studies and the creation of new chemical entities (NCEs) targeting inflammatory pathways.
• Reference Standard: Employed as a high-purity analytical standard for method development, validation, and quality control in pharmaceutical analysis.
• Biochemical Research: Utilized in academic and industrial research to study steroid receptor interactions and metabolic pathways.
• Process Chemistry: Acts as a pivotal intermediate in the scale-up and optimization of synthetic routes for complex steroid-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(6α,11β,16α,17α)-6,9-Difluoro-11-Hydroxy-16-Methyl-Spiro[Androsta-1,4-Diene-17,5'-[1,3]Oxathiolane]-2',3,4'-Trione
CAS No.	219719-95-6
Molecular Formula	C22H24F2O5S
Molecular Weight	438.49 g/mol
Synonyms	6,9-Difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-(1,3-oxathiolane-5'-spiro)-androsta-1,4-diene-17β-carbothioate; Difluoromethylprednisolone Spirothiolane Derivative; 219719-95-6; Spiro[androsta-1,4-diene-17,5'-[1,3]oxathiolane]-2',3,4'-trione, 6,9-difluoro-11-hydroxy-16-methyl-, (6α,11β,16α,17α)-; 6α,9α-Difluoro-11β-hydroxy-16α-methyl-17α-(5'-spiro-1',3'-oxathiolane)-pregna-1,4-diene-3,20-dione
EINECS	Contact for details

Quality Control

Our (6α,11β,16α,17α)-6,9-Difluoro-11-Hydroxy-16-Methyl-Spiro[Androsta-1,4-Diene-17,5'-[1,3]Oxathiolane]-2',3,4'-Trione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing including HPLC, NMR, and MS to ensure identity, purity, and conformity to specifications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.