Description

Morphine-D3 6-B-D-Glucuronide CAS NO 219533-69-4 is a stable isotope-labeled internal standard critical for quantitative bioanalytical assays. This high-purity reference material is essential for ensuring accuracy and precision in mass spectrometry-based measurements, particularly for pharmacokinetic and forensic toxicology studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and forensic science institutions for the reliable quantification of morphine and its metabolites in complex biological matrices.

Application

• Quantitative Bioanalysis: Serves as an internal standard in LC-MS/MS and GC-MS methods for the precise measurement of morphine-6-glucuronide in plasma, serum, and urine.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of metabolite formation and elimination rates in clinical trials and preclinical research.
• Forensic Toxicology: Critical for confirmatory testing and accurate quantification in post-mortem analyses and workplace drug testing programs.
• Method Development and Validation: Used as a key component in developing, optimizing, and validating robust analytical methods according to FDA, EMA, and other regulatory guidelines.
• Metabolite Profiling: Aids in the study of morphine metabolism pathways and the activity of UDP-glucuronosyltransferase enzymes.
• Quality Control for Clinical Diagnostics: Employed in the production and QC of in-vitro diagnostic (IVD) kits and calibrators for opioid testing.

Basic Information

Product Name	Morphine-D3 6-B-D-Glucuronide
CAS No.	219533-69-4
Molecular Formula	C₂₃H₂₃D₃NO₉
Molecular Weight	468.46 g/mol
Synonyms	Morphine-6-glucuronide-d3; 7,8-Didehydro-4,5-epoxy-17-methyl-(5α,6α)-morphine-3,6-diol D3 6-β-D-Glucopyranosiduronic Acid; Morphine D3 6-Glucuronide; M6G-d3; (5α,6α)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol-6-β-D-glucuronide-d3; Deuterated Morphine-6-Glucuronide; Morphine-6-β-D-glucuronide (phenyl-d5); Internal Standard for Morphine-6-Glucuronide
EINECS	Contact for details

Quality Control

Our Morphine-D3 6-B-D-Glucuronide is manufactured under strict quality systems to ensure the highest standards of purity and isotopic enrichment, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic purity (by MS), and residual solvent content. We support compliance with GMP/GLP principles for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This compound is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 99.0 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.