Description

Codeine-D3 6-B-D-Glucuronide is a stable isotope-labeled internal standard of a major human metabolite of codeine. This high-purity reference material is essential for ensuring the accuracy and reliability of quantitative analytical methods. It is primarily required by pharmaceutical R&D laboratories, forensic toxicology units, and clinical research organizations for precise drug metabolism and pharmacokinetic (DMPK) studies.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard in LC-MS/MS and GC-MS methods for the accurate quantification of codeine and its metabolites in biological matrices (plasma, urine, serum).
• Forensic Toxicology: Used in method development and validation for the definitive identification and measurement of codeine exposure in forensic and workplace drug testing.
• Clinical Pharmacology: Enables precise pharmacokinetic profiling in clinical trials studying codeine metabolism, including investigations into cytochrome P450 2D6 (CYP2D6) polymorphism effects.
• DMPK Studies: Facilitates drug metabolism and disposition studies in preclinical and clinical development phases, improving data quality for regulatory submissions.
• Reference Standard: Acts as a certified reference material (CRM) for calibrating analytical instruments and validating testing procedures in quality control laboratories.

Basic Information

Product Name	Codeine-D3 6-B-D-Glucuronide
CAS No.	219533-59-2
Molecular Formula	C25H27D3NO9
Molecular Weight	482.49 g/mol
Synonyms	Codeine D3 Glucuronide; 6-β-D-Glucopyranuronosid-17-methyl-3-methoxy-4,5α-epoxy-7,8-didehydromorphinan-6α-ol-d3; Codeine-6-β-D-Glucuronide-d3; Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5α,6α)-, 6-β-D-glucopyranosiduronic acid, 2,3,4-trideuterio-; Deuterated Codeine Glucuronide; Codeine-D3 6-Glucuronide; Internal Standard for Codeine Glucuronide
EINECS	Contact for details

Quality Control

Every batch of Codeine-D3 6-B-D-Glucuronide is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity suitable for sensitive mass spectrometry applications. A comprehensive Certificate of Analysis (COA) is provided with each lot, detailing results for assay, isotopic enrichment, and purity by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99.0 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.