Description

Ac-Ietd-Pna CAS NO 219138-21-3 is a specialized biochemical reagent, specifically a caspase-3 substrate peptide. This compound is critical for research and development in the fields of apoptosis and cell biology, serving as a key tool for detecting and quantifying caspase-3 enzyme activity. It is primarily utilized by pharmaceutical researchers, academic institutions, and diagnostic developers working on cancer therapeutics, neurodegenerative disease models, and high-throughput screening assays.

Application

• Apoptosis Research: A key substrate for the fluorometric or colorimetric detection and quantification of caspase-3 activity in cell lysates and tissue samples.
• Drug Discovery & Screening: Used in high-throughput screening (HTS) platforms to identify and evaluate novel compounds that modulate caspase-3 for potential therapeutic applications in cancer and other diseases.
• Biochemical Assay Development: Serves as a core component in developing sensitive and specific in vitro diagnostic (IVD) assays for research use.
• Academic & Institutional Research: Essential for fundamental studies in cell biology, neuroscience, and immunology to understand programmed cell death pathways.
• Quality Control in Biopharma: Can be employed in process development and quality control for biopharmaceuticals where apoptosis is a critical quality attribute.

Basic Information

Product Name	Ac-Ietd-Pna
CAS No.	219138-21-3
Molecular Formula	C27H39N7O9
Molecular Weight	605.65 g/mol
Synonyms	Ac-Ile-Glu-Thr-Asp-pNA; Ac-IETD-p-Nitroanilide; Ac-IETD-pNA; Caspase-8 Substrate I; Caspase-8 Colorimetric Substrate; N-Acetyl-Ile-Glu-Thr-Asp p-nitroanilide; Ac-Ile-Glu-Thr-Asp pNA; ICE-Like Protease (Caspase-8) Substrate
EINECS	Contact for details

Quality Control

Our Ac-Ietd-Pna is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation, to ensure it meets the high standards required for sensitive biochemical research. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO or DMF
Functional Activity	Conforms to reference standard

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.