Description

1-Palmitoyl-2-Stearoyl-(12-Doxyl)-Sn-Glycero-3-Phosphocholine is a specialized, spin-labeled phospholipid analog designed for advanced biophysical research. This compound matters because it serves as a critical molecular probe for investigating membrane dynamics, structure, and lipid-protein interactions using techniques like Electron Paramagnetic Resonance (EPR) spectroscopy. Researchers in structural biology, pharmaceutical development, and membrane biophysics need this high-purity reagent to gain insights into complex biological systems at the molecular level.

Application

• As a spin-label probe for Electron Paramagnetic Resonance (EPR) spectroscopy studies of lipid bilayer membranes.
• Investigating membrane fluidity, phase transitions, and lateral organization in model and native membranes.
• Studying the interaction and binding dynamics of membrane-associated proteins and peptides.
• Mapping local polarity and oxygen accessibility within lipid membranes.
• Use in the development and characterization of liposomal drug delivery systems and biomimetic membranes.
• Fundamental research on lipid raft formation, domain partitioning, and membrane curvature.

Basic Information

Product Name	1-Palmitoyl-2-Stearoyl-(12-Doxyl)-Sn-Glycero-3-Phosphocholine
CAS No.	217499-54-2
Molecular Formula	C₄₃H₈₄NO₈P
Molecular Weight	778.10 g/mol
Synonyms	12-Doxyl PC; 12-DOXYL-PC; 1-Palmitoyl-2-stearoyl-(12-doxyl)-sn-glycero-3-phosphocholine; PC(16:0/18:0(12-DOXYL)); Spin-labeled phosphatidylcholine; Doxyl-labeled phospholipid; EPR probe lipid; Nitroxide-labeled PC
EINECS	Contact for details

Quality Control

Our 1-Palmitoyl-2-Stearoyl-(12-Doxyl)-Sn-Glycero-3-Phosphocholine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive spectroscopic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional performance. We adhere to cGMP guidelines for research-grade biochemicals to support reproducible scientific discovery.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange waxy solid or film
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98%
Spin-Label Integrity (EPR)	≥ 95% active nitroxide radical
Solubility	Soluble in chloroform, ethanol; forms vesicles in aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.