Description

1-Palmitoyl-2-Stearoyl-(16-Doxyl)-Sn-Glycero-3-Phosphocholine is a specialized, spin-labeled phospholipid analog designed for advanced biophysical research. This compound matters for its unique ability to probe membrane dynamics, structure, and protein-lipid interactions without significantly perturbing the native bilayer. Researchers in academic institutions, pharmaceutical R&D, and biotechnology companies need it for applications in electron paramagnetic resonance (EPR) spectroscopy and as a critical tool in membrane biophysics.

Application

• Membrane Biophysics Research: As a spin-labeled lipid for studying lipid bilayer properties, phase transitions, and membrane fluidity using EPR spectroscopy.
• Protein-Lipid Interaction Studies: To investigate the binding, orientation, and conformational changes of membrane-associated proteins and peptides.
• Model Membrane Systems: Incorporation into liposomes, supported lipid bilayers, and nanodiscs to create well-defined systems for mechanistic studies.
• Drug Delivery Mechanism Analysis: Used to trace and understand the interaction of drug carriers and therapeutic agents with biological membranes.
• Oxidative Stress & Lipid Peroxidation: The doxyl spin label serves as a sensitive reporter for local oxidative damage within lipid membranes.
• Biomimetic Sensor Development: A component in the design of advanced biosensors that mimic cellular membrane environments.

Basic Information

Product Name	1-Palmitoyl-2-Stearoyl-(16-Doxyl)-Sn-Glycero-3-Phosphocholine
CAS No.	216491-65-5
Molecular Formula	C₄₃H₈₅NO₈P
Molecular Weight	775.10 g/mol
Synonyms	16-Doxyl-PC; 1-Palmitoyl-2-stearoyl-(16-doxyl)-PC; 16-DOXYL-stearoyl-PC; Spin-labeled phosphatidylcholine; PC(16:0/16-DOXYL-stearoyl); EPR Lipid Probe; Nitroxide-labeled phospholipid; 1-Palmitoyl-2-(16-doxylstearoyl)-sn-glycero-3-phosphocholine
EINECS	Contact for details

Quality Control

Our 1-Palmitoyl-2-Stearoyl-(16-Doxyl)-Sn-Glycero-3-Phosphocholine is produced under strict quality protocols to ensure high purity and batch-to-batch consistency, critical for sensitive spectroscopic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional performance. We adhere to cGMP principles where applicable to support research that may transition to pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation of the nitroxide spin label and degradation. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	Yellow to orange waxy solid or film
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (EPR)	Active spin label concentration ≥ 90%
Solubility	Soluble in chloroform, ethanol; forms liposomes in aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.