Description

γ-Linolenic Acid n-Hydroxysuccinimidyl Ester is a high-purity, activated fatty acid derivative designed for efficient bioconjugation and labeling applications. This compound is a critical reagent for researchers and manufacturers requiring the covalent attachment of γ-linolenic acid (GLA) to primary amines, such as those found on proteins, peptides, or other biomolecules. It is essential for professionals in pharmaceutical research, diagnostic assay development, and advanced material science who need reliable, site-specific modification tools. The product is supplied under stringent quality control to ensure optimal reactivity and batch-to-batch consistency for your critical workflows.

Application

• Bioconjugation Reagent: For the covalent coupling of γ-linolenic acid to antibodies, proteins, peptides, or enzymes to create fatty acid-conjugated probes.
• Pharmaceutical Research: Synthesis of novel drug conjugates, prodrugs, or targeted delivery systems where GLA is the active moiety.
• Diagnostic Development: Preparation of labeled antigens or antibodies for immunoassays (ELISA, lateral flow) and biosensors.
• Biomaterial Functionalization: Surface modification of nanoparticles, polymers, or matrices to introduce bioactive fatty acid groups.
• Lipidomics & Biochemical Studies: As a tool compound for studying lipid-protein interactions, signal transduction pathways, and metabolic labeling.
• Cross-linking Agent: Used in the preparation of cross-linked biomaterials or affinity matrices.

Basic Information

Product Name	γ-Linolenic Acid n-Hydroxysuccinimidyl Ester
CAS No.	216447-57-3
Molecular Formula	C24H35NO5
Molecular Weight	417.54 g/mol
Synonyms	GLA-NHS Ester; γ-Linolenic Acid N-Hydroxysuccinimide Ester; (6Z,9Z,12Z)-Octadecatrienoic Acid 2,5-Dioxo-1-pyrrolidinyl Ester; 6,9,12-Octadecatrienoic Acid (all-Z)-, 2,5-Dioxo-1-pyrrolidinyl Ester; N-Hydroxysuccinimidyl γ-Linolenate; NSC 339586; GLA-OSu; NHS-γ-Linolenate
EINECS	Contact for details

Quality Control

Our γ-Linolenic Acid n-Hydroxysuccinimidyl Ester is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure it meets the high standards required for research and development. Each batch is characterized by NMR, HPLC, and mass spectrometry to confirm identity, purity, and reactivity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This material is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, keep under an inert atmosphere (argon or nitrogen).

Specification

Item	Specification
Appearance	White to off-white solid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay	≥ 90% (by titration)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.