Description

(3β)-Allopregnanolone Sulfate Sodium Salt is a high-purity, water-soluble sodium salt derivative of the endogenous neurosteroid allopregnanolone. This compound is of significant interest for research into neuroactive steroids and their modulatory effects on GABA-A receptors. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic manufacturers. Its availability in a stable salt form facilitates precise formulation and experimental work in neuroscience and endocrinology.

Application

• Neuroscience Research: As a key reference standard and active agent in studies investigating GABAergic neurotransmission, neurosteroid pharmacology, and the modulation of inhibitory synaptic function.
• Biochemical Assay Development: For use in the development and validation of high-throughput screening (HTS) assays, ELISA kits, and other diagnostic tools targeting neurosteroid pathways.
• Pharmacokinetic & Metabolic Studies: Employed in ADME (Absorption, Distribution, Metabolism, Excretion) research to understand the sulfate conjugation pathway of allopregnanolone and its biological activity.
• Reference Standard for Analytical Chemistry: Serves as a certified reference material (CRM) for quantitative analysis via LC-MS/MS, HPLC, and other chromatographic techniques in bioanalytical laboratories.
• Preclinical Investigation: Used in animal model studies related to stress, anxiety, depression, epilepsy, and other neurological conditions where neurosteroid levels are implicated.

Basic Information

Product Name	(3β)-Allopregnanolone Sulfate Sodium Salt
CAS No.	215996-42-2
Molecular Formula	C21H33NaO5S
Molecular Weight	420.54 g/mol
Synonyms	Allopregnanolone Sulfate Sodium Salt; 3α-Hydroxy-5α-pregnan-20-one sulfate sodium salt; 5α-Pregnan-3α-ol-20-one sulfate sodium salt; Pregnanolone Sulfate Sodium Salt; (3α,5α)-3-Hydroxypregnan-20-one sulfate sodium salt; SGE-217 sulfate sodium salt; SGE-217-S; THDOC sulfate sodium salt analog
EINECS	Contact for details

Quality Control

Every batch of (3β)-Allopregnanolone Sulfate Sodium Salt is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency for critical research applications. A detailed Certificate of Analysis (COA) including results for assay, related substances, residual solvents, and specific tests is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.