Description

Bis(Sulfosuccinimidyl)Oxalate Sodium Salt is a high-purity, water-soluble chemical crosslinker widely used in bioconjugation and protein chemistry. This compound is valued for its ability to efficiently form stable amide bonds between primary amines under mild aqueous conditions, facilitating the labeling and immobilization of biomolecules. It is an essential reagent for researchers and manufacturers in the fields of biopharmaceutical development, diagnostic assay production, and advanced materials science, where precise and reliable conjugation is critical.

Application

• Antibody-Drug Conjugate (ADC) Development: For the site-specific conjugation of cytotoxic payloads to monoclonal antibodies.
• Diagnostic Reagent Manufacturing: Crosslinking enzymes, fluorescent dyes, or haptens to antibodies and proteins for ELISA, lateral flow, and other immunoassays.
• Biomaterial and Hydrogel Fabrication: Creating crosslinked networks for tissue engineering scaffolds and controlled drug delivery systems.
• Protein Immobilization: Covalently attaching proteins to solid supports for chromatography, biosensors, and microarray platforms.
• Peptide and Oligonucleotide Labeling: Introducing reporter groups (e.g., biotin, fluorophores) onto amine-containing biomolecules.
• Polymer Functionalization: Modifying amine-terminated polymers to introduce new functional groups or create block copolymers.

Basic Information

Product Name	Bis(Sulfosuccinimidyl)Oxalate Sodium Salt
CAS No.	215597-87-8
Molecular Formula	C10H6N2Na2O12S2
Molecular Weight	464.26 g/mol
Synonyms	BSO Sodium Salt; Disodium 3,3'-(Oxalylbis(azanediyl))bis(3-oxopropane-1-sulfonate); Disodium 2,2'-(Oxalylbis(azanediyl))di(ethanesulfonate); BS(PEG)9; Oxalic acid bis(N-hydroxysulfosuccinimide) ester disodium salt; Sulfo-BSO; Water-soluble NHS-ester crosslinker; BS(O)Na2
EINECS	Contact for details

Quality Control

Our Bis(Sulfosuccinimidyl)Oxalate Sodium Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and hydrolysis. For long-term stability, store desiccated under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Solubility (in Water)	Clear, colorless solution at 10 mg/mL
Functional Activity	Conforms (by amine coupling test)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.