Description

1-Palmitoyl-2-(16-Fluoropalmitoyl)-Sn-Glycero-3-Phosphocholine is a synthetic, fluorinated phospholipid analog designed for advanced research and development. This compound is critical for studying membrane biophysics, lipid metabolism, and the development of targeted drug delivery systems due to its unique fluorine-labeled fatty acid chain. It is primarily utilized by pharmaceutical R&D teams, academic researchers in biochemistry and biophysics, and manufacturers of diagnostic reagents and lipid nanoparticles (LNPs).

Application

• Lipid Nanoparticle (LNP) Formulation: As a component in the lipid bilayer for mRNA and siRNA delivery systems.
• Membrane Biophysics Research: As a probe to investigate lipid bilayer structure, dynamics, and phase behavior using techniques like NMR and fluorescence spectroscopy.
• Metabolic Pathway Tracing: Utilizing the fluorine-19 (19F) label as a non-radioactive tracer for studying phospholipid metabolism and trafficking.
• Model Membrane Systems: For creating defined liposomes and supported lipid bilayers (SLBs) to study protein-lipid interactions.
• Diagnostic Reagent Development: As a key intermediate or active component in advanced diagnostic assays and imaging agents.
• Pharmaceutical R&D: In the discovery and development of novel therapeutics targeting lipid-related pathways and membrane-associated proteins.

Basic Information

Product Name	1-Palmitoyl-2-(16-Fluoropalmitoyl)-Sn-Glycero-3-Phosphocholine
CAS No.	215362-14-4
Molecular Formula	C40H79FNO8P
Molecular Weight	752.04 g/mol
Synonyms	16-Fluoro-POPC; 1-Palmitoyl-2-(16-fluoropalmitoyl)-sn-glycero-3-phosphocholine; Fluorinated POPC; 16-F-POPC; (16-F)Palmitoyl-2-palmitoyl-sn-glycero-3-phosphocholine; 1-Palmitoyl-2-(16-fluorohexadecanoyl)-sn-glycero-3-phosphocholine; F-PC; Fluorolipid
EINECS	Contact for details

Quality Control

Our 1-Palmitoyl-2-(16-Fluoropalmitoyl)-Sn-Glycero-3-Phosphocholine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to ensure traceability and compliance with your research or GMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. This material is hygroscopic (moisture-sensitive) and must be handled in a dry environment. For long-term stability, desiccate the sealed container.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay (NMR / MS)	≥ 90% (by weight)
Water Content (KF)	≤ 1.0 %
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.