Description

1-Palmitoyl-2-Stearoyl-(7-Doxyl)-Sn-Glycero-3-Phosphocholine is a specialized, spin-labeled phospholipid analog, widely recognized as a critical tool in biophysical and membrane research. Its core value lies in its ability to serve as a paramagnetic probe for electron paramagnetic resonance (EPR) spectroscopy, enabling the detailed study of membrane dynamics, lipid-protein interactions, and membrane fluidity. This high-purity compound is essential for researchers and developers in the pharmaceutical, biotechnology, and academic sectors who require precise molecular tools for advanced lipidomics and drug delivery system studies.

Application

• Membrane Biophysics Research: As a spin-label for Electron Paramagnetic Resonance (EPR) spectroscopy to investigate lipid bilayer properties, phase transitions, and domain formation.
• Lipid-Protein Interaction Studies: Used to probe the interaction dynamics between membrane proteins and their lipid environment, crucial for understanding receptor function and signaling.
• Model Membrane Systems: A key component in the construction of liposomes and supported lipid bilayers (SLBs) for simulating and studying native cell membrane behavior.
• Drug Delivery Mechanism Analysis: Employed to trace and analyze the behavior, stability, and fusion mechanisms of lipid-based nanoparticle drug carriers.
• Oxidative Stress Studies: The doxyl radical serves as a reporter for local oxidative environments and free radical reactions within lipid membranes.
• Biomembrane Fluidity & Permeability: Provides critical data on membrane order, viscosity, and the impact of cholesterol or other molecules on membrane structure.

Basic Information

Product Name	1-Palmitoyl-2-Stearoyl-(7-Doxyl)-Sn-Glycero-3-Phosphocholine
CAS No.	213331-17-0
Molecular Formula	C₄₅H₈₇NO₉P
Molecular Weight	817.14 g/mol
Synonyms	7-Doxyl PC(16:0/18:0); 1-Palmitoyl-2-stearoyl-(7-doxyl)-sn-glycero-3-phosphocholine; 16:0-18:0 7-Doxyl PC; 1-Palmitoyl-2-stearoyl-sn-glycero-3-phosphocholine, 7-doxyl labeled; Spin-labeled phosphatidylcholine; Doxyl-PC; EPR Probe Lipid; 7-Doxyl phosphatidylcholine (16:0/18:0); 7-doxyl-PC(16:0/18:0)
EINECS	Contact for details

Quality Control

Our 1-Palmitoyl-2-Stearoyl-(7-Doxyl)-Sn-Glycero-3-Phosphocholine is manufactured under strict quality protocols to ensure the high purity and batch-to-batch consistency required for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen). This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and performance. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	Yellow to orange waxy solid or film
Identification (HPLC/MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay (EPR)	Active spin label content confirmed
Solubility	Soluble in chloroform, methanol, ethanol; forms liposomes in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.