Description

L-Threo-tert-Butylserine Monohydrate, 99% (99% E.E.) is a high-purity, non-proteinogenic amino acid derivative of significant synthetic utility. This compound is a critical chiral building block for the synthesis of complex pharmaceuticals and bioactive molecules, offering a protected serine side chain with defined stereochemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of peptide-based therapeutics, enzyme inhibitors, and other advanced medicinal chemistry projects.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in peptide and peptidomimetic drug discovery.
• Peptide Synthesis: Used to incorporate a sterically hindered, tert-butyl-protected serine residue into custom peptides, influencing their conformation and stability.
• Medicinal Chemistry Research: Serves as a building block for creating libraries of novel compounds for screening against biological targets.
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric reactions to construct complex molecules with high enantiomeric excess.
• Biochemical Research: Used in the study of enzyme mechanisms and as a substrate analog in biochemical assays.
• Ligand and Catalyst Development: A precursor for chiral ligands and organocatalysts used in enantioselective transformations.

Basic Information

Product Name	L-Threo-tert-Butylserine Monohydrate, 99% (99% E.E.)
CAS No.	212757-13-6
Molecular Formula	C7H15NO3 · H2O
Molecular Weight	191.21 g/mol (Anhydrous basis: 173.20 g/mol)
Synonyms	(2S,3R)-2-Amino-3-hydroxy-3,3-dimethylbutanoic Acid Monohydrate; L-threo-3-Methyl-D-serine Monohydrate; (2S,3R)-2-Amino-3-hydroxy-3-methylbutyric Acid Monohydrate; tert-Butyl-L-serine Monohydrate; L-Tert-Leucine Serine Derivative; O-tert-Butyl-L-serine Monohydrate; 212757-13-6; L-Threo-3,3-Dimethylserine Monohydrate
EINECS	Contact for details

Quality Control

This high-purity grade is manufactured under strict quality control protocols to ensure batch-to-batch consistency and reliability for sensitive applications. Every lot is characterized by advanced analytical techniques including HPLC, chiral analysis, and NMR to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation or clumping.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 99.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	Theoretical (Monohydrate)
Heavy Metals	< 10 ppm
Residue on Ignition	< 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.