Description

N,N,N',N'-Tetramethyl-S-(1-Oxido-2-Pyridyl)Thiuronium Hexafluorophosphate is a specialized organic salt widely recognized as a highly effective coupling reagent in peptide synthesis. Its primary value lies in its ability to facilitate amide bond formation with minimal racemization, ensuring high purity and yield in sensitive chemical processes. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries engaged in the development and production of peptides, peptidomimetics, and other complex organic molecules.

Application

• Peptide Synthesis: A key coupling reagent for solid-phase and solution-phase synthesis of peptides and proteins.
• Pharmaceutical Intermediates: Used in the preparation of active pharmaceutical ingredients (APIs) and complex drug candidates.
• Bioconjugation: Facilitates the linking of peptides to other molecules, such as dyes, polymers, or drug carriers.
• Organic Synthesis: Employed in the synthesis of amides, esters, and other derivatives requiring efficient coupling under mild conditions.
• Research & Development: A critical tool in academic and industrial R&D labs for exploring new synthetic methodologies and bioactive compounds.
• Combinatorial Chemistry: Used in high-throughput synthesis for generating libraries of compounds for screening.

Basic Information

Product Name	N,N,N',N'-Tetramethyl-S-(1-Oxido-2-Pyridyl)Thiuronium Hexafluorophosphate
CAS No.	212333-72-7
Molecular Formula	C11H18F6N3OPS
Molecular Weight	385.31 g/mol
Synonyms	PyOxim; TPTU; S-(1-Oxido-2-pyridinyl)-N,N,N',N'-tetramethylthiuronium Hexafluorophosphate; 2-Pyridylthiuronium Salt; PyOxim Hexafluorophosphate; 1-Oxido-2-pyridyl Tetramethylthiuronium Hexafluorophosphate; Coupling Reagent PyOxim; Tetramethyl-S-(1-oxido-2-pyridinyl)thiuronium Hexafluorophosphate
EINECS	Contact for details

Quality Control

Our N,N,N',N'-Tetramethyl-S-(1-Oxido-2-Pyridyl)Thiuronium Hexafluorophosphate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high performance. Each lot is analyzed to confirm identity, purity, and suitability for sensitive applications like peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Solubility	Soluble in acetonitrile, DMF, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.