Description

Ac-Ietd-Afc CAS NO 211990-57-7 is a high-purity, synthetic peptide derivative used as a critical biochemical tool in advanced research and development. This compound serves as a potent and selective inhibitor for specific proteolytic enzymes, enabling precise modulation of biological pathways. It is essential for researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors, particularly for applications in enzymology, apoptosis studies, and drug discovery programs.

Application

• As a key biochemical reagent in enzymatic assay development and validation.
• For targeted inhibition studies of caspases and related proteases in cellular apoptosis research.
• Utilized in high-throughput screening (HTS) platforms for identifying novel therapeutic candidates.
• As a reference standard in analytical method development for peptide-based pharmaceuticals.
• In basic research investigating signal transduction pathways and protein-protein interactions.
• For the synthesis and characterization of more complex peptide conjugates and probes.

Basic Information

Product Name	Ac-Ietd-Afc
CAS No.	211990-57-7
Molecular Formula	C30H38N6O10
Molecular Weight	642.66 g/mol
Synonyms	Ac-Ile-Glu-Thr-Asp-AFC; Ac-IETD-AFC; Ac-IETD-7-amino-4-trifluoromethylcoumarin; Caspase-8 Inhibitor (Ac-IETD-AFC); Ac-Ile-Glu(OMe)-Thr-Asp(OMe)-AFC; Ac-IETD-AFC, Fluorogenic Substrate; N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-trifluoromethylcoumarin; ICE-Like Protease Inhibitor
EINECS	Contact for details

Quality Control

Every batch of Ac-Ietd-Afc is manufactured and tested under stringent quality management systems. We guarantee high purity and batch-to-batch consistency, supported by comprehensive analytical documentation. Certificates of Analysis (COA) detailing purity (by HPLC), identity (by MS and NMR), and other critical parameters are provided to ensure it meets the exacting standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.