Description

m-Peg10-Tos CAS NO 211859-75-5 is a high-purity, monodisperse polyethylene glycol (PEG) derivative functionalized with a tosylate (p-toluenesulfonate) leaving group at one terminus. This compound is a critical intermediate in bioconjugation and pharmaceutical development, enabling the precise, controlled attachment of PEG chains to active molecules, a process known as PEGylation. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors seeking to improve the solubility, stability, and pharmacokinetic profiles of therapeutic agents.

Application

• Pharmaceutical PEGylation: A key reagent for the site-specific modification of peptides, proteins, oligonucleotides, and small molecule drugs to enhance their therapeutic properties.
• Bioconjugation Linker: Serves as a versatile linker for attaching functional molecules, dyes, or targeting ligands to biomolecules and nanoparticles.
• Polymer Chemistry: Used as a macro-initiator or monomer in the synthesis of well-defined block copolymers and functionalized polymeric materials.
• Surface Modification: Employed to create hydrophilic, non-fouling coatings on medical devices, diagnostic sensors, and other biomaterial surfaces.
• Prodrug Synthesis: Facilitates the development of prodrugs by providing a cleavable PEG spacer that can improve drug delivery and release kinetics.
• Cross-linking Agent: Acts as a hydrophilic cross-linker in the formation of hydrogels for drug delivery and tissue engineering applications.

Basic Information

Product Name	m-Peg10-Tos
CAS No.	211859-75-5
Molecular Formula	C27H56O13S
Molecular Weight	620.8 g/mol
Synonyms	Methoxy-PEG10-tosylate; α-Methyl-ω-tosyl-pentaethylene glycol; mPEG10-OTs; Monomethoxy Polyethylene Glycol 10 Tosylate; 2-[2-[2-[2-[2-[2-[2-[2-[2-(4-Methylbenzenesulfonyloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol; PEG10 Monomethyl Ether Tosylate; Tos-PEG10-OMe; p-Toluenesulfonic acid PEG ester
EINECS	Contact for details

Quality Control

Our m-Peg10-Tos is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and cGMP manufacturing. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm identity, purity, and the absence of critical impurities. Comprehensive Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is light-sensitive and should be handled under inert atmosphere when appropriate for prolonged procedures to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.