Description

Diquafosol Tetrasodium is a high-purity, synthetic nucleotide analog of diadenosine tetraphosphate (Ap4A). This compound is a potent and selective P2Y2 receptor agonist, making it a critical intermediate and active ingredient in advanced ophthalmic research and pharmaceutical development. It is primarily utilized by pharmaceutical manufacturers, biotechnology research organizations, and contract development and manufacturing organizations (CDMOs) focused on innovative dry eye disease therapies. Our supply ensures consistent quality and reliable availability for global R&D and production needs.

Application

• Active Pharmaceutical Ingredient (API) for ophthalmic solutions targeting dry eye syndrome.
• Key Intermediate in the synthesis of novel P2Y2 receptor-targeting therapeutics.
• Pharmacological Research Tool for studying purinergic signaling pathways in ocular surface diseases.
• Reference Standard for analytical method development and quality control in pharmaceutical labs.
• Formulation Development for stable, preservative-free eye drop formulations.
• Preclinical and Clinical Trial Material supply for drug development programs.

Basic Information

Product Name	Diquafosol Tetrasodium
CAS No.	211427-08-6
Molecular Formula	C18H20N10Na4O19P4
Molecular Weight	878.22 g/mol
Synonyms	Diquafosol Sodium; INS365; UR-29257; P1,P4-Di(adenosine-5') tetraphosphate, tetrasodium salt; Diadenosine tetraphosphate tetrasodium salt; Ap4A tetrasodium; 5',5'''-P1,P4-Tetraphosphoadenosine tetrasodium salt
EINECS	Contact for details

Quality Control

Our Diquafosol Tetrasodium is manufactured under strict quality systems to meet the exacting standards of the pharmaceutical industry. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure compliance with ICH guidelines for stability and impurity qualification. Our quality commitment includes traceability, validated analytical methods, and adherence to current Good Manufacturing Practice (GMP) principles for APIs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Bacterial Endotoxins	< 10 EU/mg
Microbial Enumeration	Meets Ph. Eur. 2.6.12/2.6.13 criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.