Description

Anthranilyl-HIV Protease Substrate V is a specialized fluorogenic peptide substrate designed for the sensitive and continuous assay of HIV-1 protease activity. This compound is critical for biochemical research and high-throughput screening (HTS) applications in antiviral drug discovery and development. It is an essential tool for pharmaceutical R&D laboratories, academic research institutions, and diagnostic kit manufacturers focused on HIV/AIDS research and therapeutic monitoring.

Application

• HIV-1 Protease Activity Assays: Primary substrate for fluorometric determination of protease enzyme kinetics and inhibition studies.
• Antiviral Drug Discovery: High-throughput screening (HTS) of compound libraries for potential HIV-1 protease inhibitors.
• Biochemical Research: Used in mechanistic studies of HIV protease function, substrate specificity, and resistance profiling.
• Diagnostic Development: A key component in developing in-vitro diagnostic assays for monitoring protease inhibitor efficacy.
• Enzyme Characterization: Determining kinetic parameters (Km, Vmax, kcat) of wild-type and mutant HIV-1 protease variants.
• Quality Control in Pharma: Potency testing and lot-release assays for biopharmaceuticals targeting HIV protease.

Basic Information

Product Name	Anthranilyl-HIV Protease Substrate V
CAS No.	210644-48-7
Molecular Formula	C46H62N10O11
Molecular Weight	907.05 g/mol
Synonyms	Anthranilyl-HIV Protease Substrate; HIV-1 Protease Substrate V (Anthranilyl-labeled); Abz-Thr-Ile-Nle-p-Nitro-Phe-Gln-Arg-NH2; 2-Aminobenzoyl-Thr-Ile-Nle-(p-NO2-Phe)-Gln-Arg-NH2; Fluorogenic HIV-1 Protease Substrate; Abz-T-I-Nle-(pNO2F)-Q-R-NH2; HIV PR Substrate V
EINECS	Contact for details

Quality Control

Our Anthranilyl-HIV Protease Substrate V is manufactured under strict quality systems to ensure batch-to-batch consistency and performance in sensitive assays. Each lot undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and functional validation in protease activity assays. Certificates of Analysis (COA) detailing purity, identity, and performance data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term stability, store under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Functional Activity	Conforms to reference standard
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.