Description

4-Methylumbelliferyl 6-Sulfo-2-Acetamido-2-Deoxy-B-D-Glucopyranoside, Potassium Salt is a high-purity fluorogenic substrate specifically designed for the sensitive detection and quantification of enzyme activity. This compound matters because it provides a reliable and highly specific tool for biochemical research and diagnostic assay development. It is primarily needed by researchers and manufacturers in the life sciences, pharmaceutical, and diagnostic industries for applications in enzymology and high-throughput screening.

Application

• Enzyme Assay Substrate: A critical fluorogenic substrate for the detection and kinetic study of sulfatase and glycosidase enzymes, particularly N-acetylglucosamine-6-sulfatase (G6S).
• Diagnostic Reagent Manufacturing: Used in the production of in vitro diagnostic (IVD) kits for the detection of lysosomal storage disorders, such as Mucopolysaccharidosis type III (Sanfilippo syndrome).
• Biochemical Research: Essential for fundamental research into carbohydrate metabolism, enzyme mechanisms, and the pathophysiology of related genetic diseases.
• High-Throughput Screening (HTS): Employed in pharmaceutical and biotechnology labs for screening compound libraries for modulators of specific sulfatase activities.
• Quality Control in Biologics: Acts as a specific reagent to test for the presence and activity of certain enzymes during the production and purification of therapeutic proteins.
• Cell-Based Assays: Utilized in live-cell imaging and functional assays to monitor intracellular enzyme activity within cultured cells.

Basic Information

Product Name	4-Methylumbelliferyl 6-Sulfo-2-Acetamido-2-Deoxy-B-D-Glucopyranoside, Potassium Salt
CAS No.	210357-38-3
Molecular Formula	C18H20KNO12S
Molecular Weight	513.51 g/mol
Synonyms	4-MU-6S-GlcNAc, Potassium Salt; 4-Methylumbelliferyl 6-sulfo-2-acetamido-2-deoxy-β-D-glucopyranoside, K Salt; 6-Sulfo-2-acetamido-2-deoxy-4-methylumbelliferyl-β-D-glucopyranoside, Potassium Salt; G6S Substrate; N-Acetylglucosamine-6-sulfatase Fluorogenic Substrate; 4-MU-β-GlcNAc-6S, K+; 4-Methylumbelliferyl-6-sulfo-N-acetyl-β-D-glucosaminide, Potassium Salt
EINECS	Contact for details

Quality Control

Our 4-Methylumbelliferyl 6-Sulfo-2-Acetamido-2-Deoxy-B-D-Glucopyranoside, Potassium Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and high performance in sensitive applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to meet the exacting standards required for research and diagnostic use. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, desiccate at low temperature. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Assay	95.0% - 105.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Fluorogenic Activity	Functional test passes

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.