Description

Forodesine is a potent and selective purine nucleoside phosphorylase (PNP) inhibitor, a key compound in pharmaceutical research and development. Its primary value lies in its mechanism of action, which modulates purine metabolism and lymphocyte function, making it a critical agent for investigative therapies. This product is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those focused on oncology, autoimmune disorders, and T-cell related diseases.

Application

• Pharmaceutical Intermediate: Serves as a key active pharmaceutical ingredient (API) in the development of novel therapeutics.
• Oncology Research: Investigated for its potential in treating T-cell malignancies, such as T-cell acute lymphoblastic leukemia (T-ALL) and cutaneous T-cell lymphoma.
• Autoimmune Disease Research: Studied for applications in conditions like psoriasis and rheumatoid arthritis due to its immunomodulatory effects.
• Biochemical Research: Used as a specific tool compound to study purine salvage pathways and PNP enzyme kinetics in vitro.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Preclinical & Clinical Development: Utilized in formulation studies and the production of batches for non-clinical and clinical trial materials.

Basic Information

Product Name	Forodesine
CAS No.	209799-67-7
Molecular Formula	C11H15N5O4
Molecular Weight	281.27 g/mol
Synonyms	BCX-1777; Immucillin H; (3R,4S)-1-[(9-Deazahypoxanthin-9-yl)methyl]-3-(hydroxymethyl)piperidin-4-ol; Forodesine Hydrochloride (salt form); 7-Deaza-Immucillin-H; PNP Inhibitor BCX-1777; (3R,4S)-3-(Hydroxymethyl)-1-[(1S,4R)-4-hydroxy-2-cyclopenten-1-yl]piperidin-4-ol
EINECS	Contact for details

Quality Control

Our Forodesine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results for assay, related substances, residual solvents, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.